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New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synt...

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the propo...

New substituted indazole and condensed pyrazole bisphosphonetes

New indazole and condensed pyrazole bisphosphonates

Synthesis and characterization of novel hydroxy- and aminobisphosphonates

Bisphosphonates (BPs) are a family of drugs that are successfully used in the treatment of various calcium-related disorders such as Pagetμs disease, osteoporosis and bone metastases. In addition, functional BPs have been also used in the treatment of metal intoxication and as novel ligands for well-defined radioactive metal complexes that can be used in imagiology, scintigraphy and radiotherapy applications [1...

Vanadium(IV and V) Complexes of Schiff Bases and Reduced Schiff Bases Derived f...

Several sal2en-type reduced Schiff bases have been prepared from the reaction of 2 equiv. of salicylaldehyde (or derivatives) with ethylenediamine followed by reduction with NaBH4 and subsequently characterised. The water-soluble ligands (SO3-sal)2en and R(SO3-sal)2en (SO3-sal = salicylaldehyde-5-sulphonate) have been studied by pH potentiometry and 1H NMR spectroscopy and the protonation constants of R(SO3-sal...

A supramolecular zigzag chain of organometallic dipoles mediated by PF6 2- anions

Complex Fe( 5-cyclopentadienyl)(PMe3)[P(OPh)3](4–NCC6H4NO2) [PF6] has been characterized by spectroscopic and X-ray diffraction in order to evaluate the tuning of the electron density at the metal center and the extension ofthe delocalization on the molecule due to the presence of phosphite and phosphine co-ligands. The compound crystallizes in the centrosymmetric space group P21/c which destroys the possibil...

N,N'-Ethylenebis(pyridoxylideneiminato) and N,N'-Ethylenebis(pyridoxylaminato):...

The Schiff base N,Nprime-ethylenebis(pyridoxylideneiminato) (H2pyr2en, 1) was synthesized by reaction of pyridoxal with ethylenediamine; reduction of H2pyr2en with NaBH4 yielded the reduced Schiff base N,Nprime-ethylenebis(pyridoxylaminato) (H2Rpyr2en, 2); their crystal structures were determined by X-ray diffraction. The totally protonated forms of 1 and 2 correspond to H6L4+, and all protonation constants wer...

Synthesis of new donor/acceptor 5-cyclopentadienyl and 5-indenyliron(II) comp...

New complexes of the type [Fe( 5-Cp or Ind)(L)(L )(p-NCR)][BF4] (L, L =CO, P(OC6H5)3, P(C6H5)3; R=C6H4N(CH3)2, C6H4NO2, (E)-C(H) C(H)C6H4NO2, (E)-C(H) C(H)C6H4N(CH3)2) have been synthesised and characterised. Spectroscopic data were analysed in order to evaluate the tuning of the electronic density at the metal centre and the extension of the -delocalisation on the molecule, due to the presence of coligands w...

Organometallic nickel(II) complexes with substituted benzonitrile ligands. Synt...

A new family of organometallic Ni II benzonitrile derivatives bearing strong donor substituents of general formula Ni - C H P C H NCC H R PF R NH , N CH , C H , OCH , H, F has been synthesized. A structural study by X-ray 5 5 6 5 3 6 4 6 2 3 2 6 5 3 diffraction of the compound with R NH showed crystallization on the centrosymmetric monoclinic space group, P2 n, with a quasi 2 1 planar structure of the coordinat...