Encontrados 2 documentos, a visualizar página 1 de 1
Macrocyclic and polymeric lanthanide chelates: from physico-chemical studies to...
Duarte, M. G.; Prata, M. I. M.; Gil, M. H. M.; Geraldes, C. F. G. C.The improvement of commonly used Gd3+-based MRI contrast agents requires the design of new chelates with optimised in vivo efficacy, pharmacokinetic properties and specificity. The molecular parameters determining the nuclear relaxivity of the cationic chelate [Gd(DO2A)]+, as well as of some copolymers of [Gd(DTPA)]2- with diamines, were obtained using spectroscopic techniques. In both cases, the resulting too ...
Synthesis, Characterization, and Relaxivity of Two Linear Gd(DTPA)−Polymer Conj...
Duarte, M. G.; Gil, M. H.; Peters, J. A.; Colet, J. M.; Elst, L. Vander; Muller, R. N.; Geraldes, C. F. G. C.Two linear polyamide conjugates of Gd(DTPA)2- were synthesized and characterized by high-resolution nuclear magnetic resonance (NMR) spectroscopy and size exclusion chromatography (SEC). DTPA was copolymerized with two different diamines, 1,6-hexanediamine and trans-1,4-cyclohexanediamine, yielding the polymers DTPA-HMD and DTPA-CHD, with low polydispersity. Their molecular flexibility in solution was studied u...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||