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Molecular modeling of the interaction of novel hydroxy-and aminobisphosphonates...
Duarte, L. F.; Teixeira, Fátima C.; Fausto, R.Bisphosphonates (BPs) are a class of drugs widely used in the treatment of several metabolic bone disorders associated with increased bone resorption. Although BPs can directly inhibit the cellular activity of osteoclasts, their ability to adsorb on bone mineral is also an important factor in determining their potency and duration of action. In this study, we performed a molecular mechanics analysis of the mole...
Molecular modelling of the interaction of novel hydroxybisphosphonates with hyd...
Duarte, L. F.; Teixeira, Fátima C.; Fausto, R.Bisphosphonates (BPs) are a class of drugs widely used in the treatment of several metabolic bone disorders associated with increased bone resorption, including osteoporosis, Paget’s disease and metastic bone disease [1-3]. Although BPs can directly inhibit the cellular activity of osteoclasts, their ability to adsorb to bone mineral is also an important factor in determining their potency and duration of actio...
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