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Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Ene...

Mitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycles of 2.5 mg/kg MTX at day 0, 10, and 20. One treated group was euthanized on day 22 (MTX22) to evaluate the early...

Like branches in a river:viagens estrada afora e cidade adentro no cinema ameri...

Tese de doutoramento, Estudos de Literatura e de Cultura (Estudos Americanos), Universidade de Lisboa, Faculdade de Letras ; O presente trabalho tem como objectivo inquirir sobre a importância da viagem no cinema americano contemporâneo, tendo sido considerados dois espaços cinematográficos: por um lado, a estrada – especificamente no road movie – e, por outro, a cidade – num tipo de filme que dialoga com este...

Development and operation of a Bluetooth demonstrator

Wireless communications in distributed and/or embedded systems is an important research topic today. One of the emerging standards in this domain is Bluetooth. In this paper a demonstrator of embedded devices connected with Bluetooth is presented. The demonstrator is used to show the development technology available at our laboratory. So, besides the description of its operation, t...

Efeito de um programa de exercício físico de longa duração no controlo glicémic...

Os efeitos benéficos da prática regular de exercício físico (EF) na melhoria do controlo glicémico em doentes com diabetes mellitus do tipo 2 (DM2), estão relativamente bem documentados na literatura, nomeadamente em programas de curta e média duração. Menos consenso existe relativamente ao longo prazo. No presente estudo, procurou-se avaliar os efeitos de um programa de EF regular de longa duração no controlo ...

Da beleza das almas: para uma autópsia do corpo físico e social em Six feet und...

Tese de mestrado, Estudos Anglísticos, Universidade de Lisboa, Faculdade de Letras, 2009 ; A morte sempre foi um dos grandes desafios da vida. A vontade de perenidade do corpo sustenta esse desafio e a relação que cada ser humano mantém com esta ideia é complexa, tendo originado rituais que vão evoluindo com os tempos. Em particular numa sociedade como a americana, a história mostra que a evolução das formas ...

Involvement of advanced glycation end products in the pathogenesis of diabetic ...

Advanced glycation end products (AGEs) may play an important role in the pathogenesis of chronic diabetic complications and in the natural process of biological aging. In fact, maintained hyperglycaemia favours the formation of AGEs at the tissue level in diabetic patients, which may influence the triggering of different chronic pathologies of diabetes such as retinopathy, nephropathy, neuropathy and macro- and...

Influence of hormonal replacement therapy in lipid peroxidation levels of postm...

It has been suggested that exercise has a positive impact on the prevention and progression of cardiovascular disease (CVD). One of the main mechanisms is through the modification of lipoprotein levels and the risk of its oxidation, especially LDL lipoproteins. After menopause, women experience an increased incidence of cardiovascular disease. In contrast, women receiving hormonal replacement therapy (HRT) seem...

Chemical reactivity of paraquat with the previously validated antidote, sodium ...

Reactivity of paraquat with sodium salicylate: Formation of stable complexes

Sodium salicylate (NaSAL) has been shown to be a promising antidote for the treatment of paraquat (PQ) poisonings. The modulation of the pro-oxidant and pro-inflammatory pathways, as well as the antithrombogenic properties of NaSAL are probably essential features for the healing effects provided by this drug. Nevertheless, a possible direct chemical reactivity between PQ and NaSAL is also a putative pathway to ...

Morphologic and systemic alterations in obese and overweight subjects after a p...

There are some evidences that exercise training reduces total and abdominal fat and some systemic variables with improve health benefits. The sim of this study was to ana1yse the variation of some morphologic and systemic variables in 16 (age-64.5±7.2) obese and overweight (BM!=31.4o±5.7) type 2 diabetic patieots, of hoth gender, dutiog a regular physical exercisc program, which consists of 3 5 minutes of fast ...