Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to eva...
Mitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycles of 2.5 mg/kg MTX at day 0, 10, and 20. One treated group was euthanized on day 22 (MTX22) to evaluate the early...
Tese de doutoramento, Estudos de Literatura e de Cultura (Estudos Americanos), Universidade de Lisboa, Faculdade de Letras ; O presente trabalho tem como objectivo inquirir sobre a importância da viagem no cinema americano contemporâneo, tendo sido considerados dois espaços cinematográficos: por um lado, a estrada – especificamente no road movie – e, por outro, a cidade – num tipo de filme que dialoga com este...
Resultados de estudos longitudinais sugerem que em longo prazo, a obesidade durante a infanda está associada com um aumento do risco de obesidade em adulto, e também um aumento da morbilidade c mortalidade nos adultos. Devido aos reconhecidos problemas de saúde associados à obesidade, seria fundamental prevenir a obesidade na vida adulta através da diminuição da prevalência deste estado durante a infância e juv...
Actualmente as doenças cardiovasculares (DCV) são uma das maiores causas de morte no mundo industrializado. Existem evidências sugerindo que os factores de risco dessas doenças têm a sua origem já na infância. Deste modo, medidas preventivas devem ser implementadas em crianças e adolescentes, uma vez que a hipertensão arterial (HTA) e a obesidade são considerados factores de risco major para as DCV. Os objectiv...
This thesis studies infrared wireless local area networks, considering simultuneously the physical link and medium access aspects. A general description of free-space infrared physical links is carried out, with the main purpose of characterising and comparing quasi-diffuse and diffuse cells (in quasi-diffuse cells the optical connection between stations is through a single reflector while in the diffuse cells ...
The work to be presented was motivated by a contribution to the design of an optical receiver for use in an all-optical cable television distribution network, and evolves over the field of Linearization of amplifiers based on GaAs MESFET devices. (...)Keywords: amplifiers; linearization; intermodulation; distortion; cable televisionPh.D., 1996more info. http://opac.ua.pt/F/?func=find-b&find_code=S...
Abstract. Nowadays the use of computational design processes in architecture is a common practice which is currently recovering a set of theories connected to computer science that were developed in the 60s and 70s. Such pioneering explorations were marked by an interest in employing scientific principles and methodologies many developed in Research Centres located in the US and the UK. Looking into this period...
International guidelines recommend a first line therapy in the treatment of female stress urinary incontinence (SUI), the pelvic floor muscle (PFM) training. This case report assesses the effects of the PFM training program in treating women with severe SUI. The urodynamic parameters allow diagnosed intrinsic sphincter deficiency and urethral hypermobility. The subjective and objective parameters were assessed ...
Dissertação apresentada para obtenção do grau de Doutor em Engenharia Mecânica, na especialidade de Tecnologia Mecânica, na Faculdade de Engenharia da Universidade do Porto
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