Encontrados 5 documentos, a visualizar página 1 de 1
Driving GDNF expression: The green and the red traffic lights
Saavedra, Ana; Baltazar, Graça; Duarte, Emília P.http://www.sciencedirect.com/science/article/B6T0R-4TCYCK1-4/2/6ab005aaac74c472a6f5d27aaa505084
Cardosins improve neuronal regeneration after cell disruption: a comparative ex...
Duarte, Ana; Duarte, Emília; Correia, António; Pires, Euclides; Barros, MarleneAbstract The establishment of primary cell cultures is invaluable for studying cell and molecular biological questions. Although primary cell cultures more closely resemble and function like in the native environment, during the culture establishment the cells undergo several changes including the damage sustained during their removal from original tissue. The resultant cells have to rebalance the expression o...
Intracellular signaling mechanisms mediating catecholamine release upon activat...
Rosmaninho-Salgado, Joana; Araújo, Inês M.; Álvaro, Ana Rita; Duarte, Emília P.; Cavadas, CláudiaThe adrenal chromaffin cells synthesize and release catecholamine (mostly epinephrine and norepinephrine) and different peptides, such as the neuropeptide Y (NPY). NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release f...
GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures
Saavedra, Ana; Baltazar, Graça; Carvalho, Caetana M.; Duarte, Emília P.Heme oxygenase-1 (HO-1) has been strongly highlighted because of its induction in many cell types by toxic stimuli, including oxidative stress. The intense HO-1 immunostaining in the substantia nigra of Parkinson disease (PD) patients suggests its involvement in the pathogenesis of this neurodegenerative disease. In this work we investigated HO-1 expression in rat substantia nigra postnatal cell cultures under ...
Differential Expression of Syntaxin 1A and 1B by Noradrenergic and Adrenergic C...
Baltazar, Graça; Carvalho, Arsélio P.; Duarte, Emília P.The expression and localization of syntaxin isoforms 1A and 1B in adrenergic and noradrenergic chromaffin cells were examined by both immunoblot analysis and confocal immunofluorescence microscopy. Syntaxin 1A was found in higher levels in noradrenergic cells, whereas syntaxin 1B was similarly expressed in most noradrenergic and adrenergic cells. However, some heterogeneity was observed within each catecholamin...
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