Encontrados 15 documentos, a visualizar página 1 de 2
Effect of the matrix system in the delivery and in vitro bioactivity of microen...
Costa, Sara Beirão da; Duarte, Cláudia; Bourbon, A. I.; Pinheiro, A. C.; Serra, Ana Teresa; Martins, Margarida Moldão; Januário, Maria Isabel NunesThe effect of encapsulating matrix on retention, protection and delivery of Oregano essential oil (EO) was studied. EO was encapsulated in rice starch porous spheres, inulin and gelatine/sucrose capsules by spray drying. Gelatine/sucrose matrix was also dried by freeze drying. Experimental designs were applied to test the effect of bonding agents and solids content for rice starch and drying temperature and sol...
As Questões de Género na Publicidade: Percepções de Estudantes e Profissionais ...
Duarte, Catarina Ribeiro ArnautGestão de Serviços ; Master in Services Management
Microplate-based high throughput screening procedure for the isolation of lipid...
Pereira, Hugo; Barreira, Luísa Paula Viola Afonso; Mozes, Andre; Florindo, C.; Polo, Cristina; Duarte, Catarina V; Custódio, Luísa Margarida BatistaAbstract We describe a new selection method based on BODIPY (4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene) staining, fluorescence activated cell sorting (FACS) and microplate-based isolation of lipid-rich microalgae from an environmental sample. Our results show that direct sorting onto solid medium upon FACS can save about 3 weeks during the scale-up process as compared with the growth of the...
Reactivity of human fetal and adult immortalized hepatocytes to potentially tox...
Duarte, Catarina Vizetto GuerreiroDissertação apresentada para a obtenção do Grau de Mestre em Genética Molecular e Biomedicina, pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia ; Cholestasis is the reduction or stoppage of bile flow. When bile flow is interrupted, the bile compounds, namely bile acids and bilirubin, accumulate into the hepatocyte causing cellular injury and cell death. The hepatocyte function under cholest...
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives
Braga, Mara E. M.; Pato, Maria T. Vaz; Silva, Hélio S. R. Costa; Ferreira, Elisabeth I.; Gil, Maria H.; Duarte, Catarina M. M.; Sousa, Hermínio C. deIn this work, three chitosan derivatives (N-carboxymethyl chitosan (CMC), N-carboxybutyl chitosan (CBC) and N-succinyl chitosan (SCC)) were impregnated with flurbiprofen (an anti-inflammatory drug) and timolol maleate (an anti-glaucoma drug), using a supercritical solvent impregnation (SSI) technique (and employing high pressure CO2 and CO2 + EtOH mixtures) in order to develop hydrogel-type ophthalmic drug deli...
Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug...
Duarte, Ana Rita C.; Simplicio, Ana Luísa; Vega-González, Arlette; Subra-Paternault, Pascale; Coimbra, Patrícia; Gil, M. H.; Sousa, Hermínio C. deSupercritical fluid impregnation was tested to prepare a new ophthalmic drug delivery device. Poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate), P(MMA-EHA-EGDMA) has been proposed by Mariz [M. Mariz, Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco, Master Thesis, Universidade de Coimbra, 1999] as a promising matrix to be used for intraoc...
Supercritical antisolvent precipitation of PHBV microparticles
Costa, M. S.; Duarte, Ana Rita C.; Cardoso, M. M.; Duarte, Catarina M. M.The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SASexperiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mwere obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size d...
Preparation of acetazolamide composite microparticles by supercritical antisolv...
Duarte, Ana Rita C.; Roy, C.; Gonzalez, A. V.; Duarte, Catarina M. M.; Subra-Paternault, PascaleThe possibility of preparation of ophthalmic drug delivery systems using compressed anti-solvent technology was evaluated. and RL 100 were used as drug carriers, acetazolamide was the model drug processed. Compressed anti-solvent experiments were carried out as a semi-continuous or a batch operation from a liquid solution of polymer(s) + solute dissolved in acetone. Both techniques allowed the recovery of comp...
Sorption and diffusion of dense carbon dioxide in a biocompatible polymer
Duarte, Ana Rita C.; Martins, Carlos; Coimbra, Patrícia; Gil, Maria H. M.; Sousa, Hermínio C. de; Duarte, Catarina M. M.Mass sorption and diffusion coefficients in one acrylate biocompatible copolymer contacted with supercritical (sc) carbon dioxide are reported. Equilibrium solubility of dense carbon dioxide in poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate) (P(MMA-EHA-EGDMA)) was studied by a gravimetric method in a temperature range from 308 to 323 K and a pressure range from 10.0 to 20.0 MPa. T...
Supercritical polymerization and impregnation of molecularly imprinted polymers...
Duarte, Ana Rita C.; Casimiro, T.; Duarte, A. A.; Simplicio, A. L.; Duarte, Catarina M. M.Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules,...
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