Encontrados 60 documentos, a visualizar página 1 de 6
GABAA receptor dephosphorylation followed by internalization is coupled to neur...
Mele, Miranda; Ribeiro, Luís; Inácio, Ana R.; Wieloch, Tadeusz; Duarte, C. B.Cerebral ischemia is characterized by an early disruption of GABAergic neurotransmission contributing to an imbalance of the excitatory/inhibitory equilibriumand neuronal death, but the molecular mechanisms involved are not fully understood. Here we report a downregulation of GABAA receptor (GABAAR) expression, affecting both mRNA and protein levels of GABAAR subunits, in hippocampal neurons subjected to oxygen...
Coexisting primary Sjögren’s syndrome and sarcoidosis: coincidence, mutually ex...
Santiago, T; Santiago, M; Rovisco, R; Ferreira, J; Duarte, C; Malcata, A; Pereira da Silva, JAHerein, we describe a 44-year-old female diagnosed with histologically proven coexistence of primary Sjögren's syndrome and sarcoidosis with pulmonary and muscular involvement. The differential diagnosis may be difficult, but this is not an exceptional case, which highlights the need to critically revise the consideration of sarcoidosis as an exclusion for primary Sjögren's syndrome, as established in current c...
Characterization of polymorphic microsatellite loci in the Antarctic krill Euph...
Candeias, R.; Teixeira, Sara; Duarte, C. M.; Pearson, G. A.Background: The Antarctic krill, Euphausia superba is a pelagic crustacean, abundant in high-density swarms (10 000 – 30 000 ind/m2) with a circumpolar distribution and a key role in the food web of the Southern Ocean. Only three EST derived microsatellite markers have been used in previous genetic studies, hence we developed additional highly polymorphic microsatellite markers to allow robust studies of the ge...
Planeamento de Trajectórias usando Caminhos de Curvatura Contínua
Duarte C. Leão; Tiago C. Pereira; Pedro A. Lima; Luís M. M. CustódioThis paper proposes a method for real-time planning of continuous curvature paths in a structured environment. The building blocks of such paths are circle segments, straight-line segments and clothoids — the later being used to smoothly adapt the curvature profile of the resulting paths. The main application for this method would be to provide guidance for autonomous vehicles in a formula one like enviro...
Identification of clinical predictors of flare in systemic lupus erythematosus ...
Inês, L; Duarte, C; Silva, RS; Teixeira, AS; Fonseca, FP; Pereira da Silva, JAObjective. SLE has a relapsing-remitting course with disease activity flares over time. This study aims to identify clinical predictors of SLE flares.Methods. This prospective cohort study over 24 months included all SLE patients on follow-up at one academic lupus clinic. Flare was defined as an increase in SLEDAI-2K score ≥4 points. Baseline clinical and demographic parameters were compared using survival anal...
A case of infliximab-induced lupus in a patient with ankylosing spondylitis: is...
Santiago, T; Santiago, MG; Rovisco, J; Duarte, C; Malcata, A; Pereira da Silva, jaAnti-TNF-α therapies are the latest class of medications found to be associated with drug-induced lupus, a distinctive entity known as anti-TNF-α-induced lupus (ATIL) (Williams et al., Rheumatology (Oxford) 48:716-20, 2009; De Rycke et al., Lupus 14:931-7, 2005; De Bandt et al., Clin Rheumatol 22:56-61, 2003). With the widespread use of these agents, it is likely that the incidence of ATIL will increase. The on...
Ecocardiografia Transesofágica e Cirurgia Vascular
Duarte, CSegundo as guidelines atuais, o ecocardiograma transesofágico está indicado na cirurgia vascular major. O objetivo deste trabalho é determinar qual é o impacto do ecocardiograma transesofágico no diagnóstico de patologias da aorta susceptíveis de correção cirúrgica, na orientação da abordagem anestésica e cirúrgica e na monitorização destes pacientes no pós-operatório. Para o efeito, os seguintes itens foram es...
Entangled effects of allelic and clonal (genotypic) richness in the resistance ...
Massa, S. I.; Paulino, Cristina M.; Serrão, Ester; Duarte, C. M.; Arnaud-Haond, S.Background - The relationship between species diversity and components of ecosystem stability has been extensively studied, whilst the influence of the genetic component of biodiversity remains poorly understood. Here we manipulated both genotypic and allelic richness of the seagrass Zostera noltii, in order to explore their respective influences on the resistance of the experimental population to stress. Thus ...
Invasion is a community affair: clandestine followers in the bacterial communit...
Aires, T.; Serrão, Ester; Kendrick, G.; Duarte, C. M.; Arnaud-Haond, S.Biological invasions rank amongst the most deleterious components of global change inducing alterations from genes to ecosystems. The genetic characteristics of introduced pools of individuals greatly influence the capacity of introduced species to establish and expand. The recently demonstrated heritability of microbial communities associated to individual genotypes of primary producers makes them a potentiall...
Síndrome de Churg-Strauss: casuística
Alfaro, TM; Duarte, C; Monteiro, R; Simão, A; Calretas, S; Nascimento-Costa, JMChurg-Strauss syndrome (CSS) is a systemic necrotizing vasculitis of the small and medium vessels, associated with extravascular eosinophilic granulomas, peripheral eosinophilia and asthma. This is a rare syndrome of unknown etiology, affecting both genders and all age groups. CSS patients usually respond well to steroid treatment, although relapses are common after it ends. Timely diagnosis and treatment gener...
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