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Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioen...
Rato, Luis; Duarte, Ana I.; Tomás, Gonçalo D.; Santos, M. S.; Moreira, Paula I.; Socorro, Silvia; Cavaco, José E.; Alves, Marco G.; Oliveira, Pedro F.Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at testicular level. Peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α) and Sirtuin 3 (Sirt3) are pivotal inmitochondrial function. We hypothesized that pre-diabetes disrupts testicular PGC-1α/Sirt3 axis, compromising testicular mitochondrial function. Using a high-energy-diet induced pre-diabetic rat model,...
Insulin restores metabolic function in cultured cortical neurons subjected to o...
Duarte, Ana I.; Proença, Teresa; Oliveira, Catarina R.; Santos, Maria S.; Rego, A. CristinaWe previously demonstrated that insulin has a neuroprotective role against oxidative stress, a deleterious condition associated with diabetes, ischemia, and age-related neurodegenerative diseases. In this study, we investigated the effect of insulin on neuronal glucose uptake and metabolism after oxidative stress in rat primary cortical neurons. On oxidative stress, insulin stimulates neuronal glucose uptake an...
Valsartan improves mitochondrial function in hearts submitted to acute ischemia
Monteiro, Pedro; Duarte, Ana I.; Gonçalves, Lino M.; Providência, Luís A.The effect of valsartan, an angiotensin II-type I receptor blocker, on the mitochondrial function, was studied using an ex vivo animal model (hearts from Wistar rats), perfused in a Langendorff system and then submitted to global acute ischemia. Parameters evaluated were: membrane electrical potential ([Delta][Psi], using a tetraphenylphosphonium-TPP+-electrode), oxygen consumption by the respiratory chain (Cla...
Protective effect of trimetazidine on myocardial mitochondrial function in an e...
Monteiro, Pedro; Duarte, Ana I.; Gonçalves, Lino M.; Moreno, António; Providência, Luís A.Trimetazidine is an anti-ischemic drug whose cytoprotective mechanisms are not yet fully understood (but until now mainly related to the trimetazidine-induced "metabolic shift" from lipid [beta]-oxidation to glucose aerobic oxidation). We studied the effect of trimetazidine on the mitochondrial function of ischemic Wistar rat hearts perfused with glucose, using a model of ex-vivo perfusion (Langendorff system)....
Oxidative stress affects synaptosomal gamma-aminobutyric acid and glutamate tra...
Duarte, Ana I.; Santos, Maria S.; Seiça, Raquel; Oliveira, Catarina R.Evidence suggests that oxidative stress is involved in the pathophysiology of diabetic complications and that insulin has a neuroprotective role in oxidative stress conditions. In this study, we evaluated the in vitro effect of insulin in the susceptibility to oxidative stress and in the transport of the amino acid neurotransmitters γ-aminobutyric acid (GABA) and glutamate in a synaptosomal fraction isolated fr...
Carvedilol improves energy production during acute global myocardial ischaemia
Monteiro, Pedro; Duarte, Ana I.; Moreno, António; Gonçalves, Lino M.; Providência, Luís A.Cardiac mitochondria may become dysfunctional during ischaemia, thus compromising cardiomyocyte function. Carvedilol is an [alpha]1/[beta]-adrenoceptor antagonist with antioxidant, neuroprotective, cardioprotective and vascularprotective properties, and is used to treat hypertension, myocardial ischaemia and congestive heart failure. However, its impact on mitochondrial function during acute prolonged ischaemia...
Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress mod...
Pereira, Cláudia; Agostinho, Paula; Moreira, Paula I; Duarte, Ana I; Santos, Maria S; Oliveira, Catarina RReactive oxygen species (ROS) play an important role in neuronal damage and death that occurs in several neurodegenerative disorders, namely in Alzheimer's disease (AD). The observation that ROS neutralization may slow or reduce the neurodegenerative process associated with those pathologies stimulates the development of new drugs, more efficient and well tolerated, with antioxidant properties. Vinpocetine [14-...
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