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Persistência de Klebsiella pneumoniae em doentes de unidades pediátricas do Hos...
Cerqueira, Sofia Arriaga; Machado, Paula; Marto, Joana; Lito, Luís; Melo-Cristino, José; Duarte, AidaIntrodução: A Klebsiella pneumoniae é responsável por infecções nosocomiais e adquiridas na comunidade. A produção de β-lactamases de espectro alargado (ESBLs) e os factores de virulência assumem particular importância nestas infecções.
Exploitation of a link between antibacterial agent-resistance and biofilm-forma...
João, Inês; Reis, Lúcia; Carvalho, Patrícia; Duarte, Aida; Jordão, LuisaObjectives: In recent years nosocomial infections have gained growing importance. Among their etiological agents are “classical” pathogens such as S.aureus and also emergent pathogens, previously neglected, such as nontuberculous mycobacteria (MTM). The ability to resist to antibacterial agents, such as antibiotics and disinfectants, is shared by all of them. Here we aim to establish a link between bacterial vi...
Exploring a link between pathogens structure's and resistance to
João, Inês; Reis, Lúcia; Carvalho, Patrícia; Duarte, Aida; Jordão, LuisaIn recent years healthcare-associated infections (HAIs) infections have gained growing importance. Among their etiological agents are classical (e.g. K. pneumoniae, S. aureus) and emergent pathogens, previously neglected, such as nontuberculous mycobacteria (NTM). The ability to resist to antibacterial agents, such as antibiotics and disinfectants, is shared by all of them. Here we aim to establish a link betwe...
Bacterial biofilms, antibiotic resistance and healthcare-associated infections:...
Bandeira, Maria; Carvalho, Patrícia; Duarte, Aida; Jordão, LuisaIn 2012, were estimated 6.7 million cases of healthcare-associated infections (HAI) either in long-term care facilities or acute-care hospitals from which result 37,000 deaths configuring a serious public health problem [1]. The etiological agents are diverse and often resistant to antimicrobial agents. One of the mechanisms responsible for the emergence of drug resistance is biofilm assembly. Biofilms are defi...
Chemical composition and antibacterial activity of essential oils from the medi...
Rodrigues, Leandra; Duarte, Aida; Figueiredo, Ana Cristina; Brito, Luísa; Teixeira, Generosa; Moldão, Margarida; Monteiro, AnaMentha cervina is a medicinal plant traditionally used in Portugal in folk medicine, in different gastric disorders and inflammations of the respiratory tract. In order to validate those traditional uses, M. cervina essential oils (EOs) were characterized by GC and GC–MS and their antimicrobial activity was tested against 23 bacterial strains (including multiresistant strains). The EOs were dominated by the mon...
ABIETANE DITERPENOIDS FROM PLECTRANTHUS GRANDIDENTATUS
Teixeira, António P.; Batista, Olga; Simões, M. Fátima; Nascimento, J.; Duarte, Aida; Torre, Maria C. de la; Rodriguez, BenjaminThe acetone extract of the whole plant of Plectranthus grandidentatus provided the already known abietanes royleanone, 6,7-dehydroroyleanone, horminone, 6β-hydroxyroyleanone, 7α-acetoxy-6β-hydroxyroyleanone and the abietane dimers grandidone C, grandidone D and 7-epigrandidone D, together with a mixture of fatty acid esters of 7α-acyloxy-6β,12-dihydroxy-abieta-8,12-diene-11,14-dione. Some of these compounds sho...
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