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Valsartan improves mitochondrial function in hearts submitted to acute ischemia
Monteiro, P; Duarte, AI; Gonçalves, L; Providência, LAThe effect of valsartan, an angiotensin II-type I receptor blocker, on the mitochondrial function, was studied using an ex vivo animal model (hearts from Wistar rats), perfused in a Langendorff system and then submitted to global acute ischemia. Parameters evaluated were: membrane electrical potential (DeltaPsi, using a tetraphenylphosphonium-TPP+-electrode), oxygen consumption by the respiratory chain (Clark-t...
Protective effect of trimetazidine on myocardial mitochondrial function in an e...
Monteiro, P; Duarte, AI; Gonçalves, L; Moreno, AJ; Providência, LATrimetazidine is an anti-ischemic drug whose cytoprotective mechanisms are not yet fully understood (but until now mainly related to the trimetazidine-induced "metabolic shift" from lipid beta-oxidation to glucose aerobic oxidation). We studied the effect of trimetazidine on the mitochondrial function of ischemic Wistar rat hearts perfused with glucose, using a model of ex-vivo perfusion (Langendorff system). W...
O Carvedilol Protege Mitocôndrias Cardíacas Isquémicas de Lesões Induzidas Por ...
Carreira, R; Duarte, AI; Monteiro, P; Santos, MS; Rego, AC; Oliveira, CR; Gonçalves, L; Providência, LAIschemia negatively affects mitochondrial function by inducing the mitochondrial permeability transition (MPT). The MPT is triggered by oxidative stress, which occurs in mitochondria during ischemia as a result of diminished antioxidant defenses and increased reactive oxygen species production. It causes mitochondrial dysfunction and can ultimately lead to cell death. Therefore, drugs able to minimize mitochond...
O Piruvato Melhora A Energética Mitocondrial Num Modelo Animal Ex-vivo de Isque...
Monteiro, P; Duarte, AI; Moreno, AJ; Gonçalves, L; Providência, LAPyruvate is an energy substrate with known cardioprotective activity. We know now that this is due not only to its antioxidant activity, but also to its reduction of intracellular acidosis, modulation of intracytosolic calcium and improvement of cardiomyocyte contractility. However, the role of cardiac mitochondria in such positive effects has only recently begun to be understood and the exact mechanisms of the...
Carvedilol improves energy production during acute global myocardial ischaemia
Monteiro, P; Duarte, AI; Moreno, AJ; Gonçalves, L; Providência, LACardiac mitochondria may become dysfunctional during ischaemia, thus compromising cardiomyocyte function. Carvedilol is an alpha(1)/beta-adrenoceptor antagonist with antioxidant, neuroprotective, cardioprotective and vascularprotective properties, and is used to treat hypertension, myocardial ischaemia and congestive heart failure. However, its impact on mitochondrial function during acute prolonged ischaemia i...
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