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Population mobility and the changing epidemics of HIV-2 in Portugal
Carvalho, A; Valadas, E; França, L; Carvalho, C; Aleixo, M; Mendez, J; Marques, R; Sarmento, A; Doroana, M; Antunes, F; Branco, T; Águas, M; Castro, RINTRODUCTION: Portugal is the European country with the highest frequency of HIV-2 infection, which is mainly concentrated in West Africa. The cumulative number of notified HIV-2 infections in Portugal was 1813 by the end of December 2008. To better characterize the dynamics of HIV-2 infection in the country and to obtain data that may be of use in the prevention of the spread of HIV-2, we evaluated a large poo...
Recent advances in antiretroviral treatment and prevention in HIV-infected pati...
Maltez, F; Doroana, M; Branco, T; Valente, CPURPOSE OF REVIEW: To discuss new antiretroviral agents (ARVs) and alternative ARV treatment strategies that are currently being evaluated, and to provide an overview of the most recent advances in HIV vaccine development. RECENT FINDINGS: There is a continuous need for improvements in ARV therapy (ART) and several new ARVs are currently undergoing clinical investigation, including the non-nucleoside reverse tr...
The Role of the Humoral Immune Response in the Molecular Evolution of the Envel...
Borrego, P; Marcelino, JM; Rocha, C; Doroana, M; Antunes, F; Maltez, F; Gomes, P; Novo, C; Barroso, H; Taveira, NBACKGROUND: This study was designed to investigate, for the first time, the short-term molecular evolution of the HIV-2 C2, V3 and C3 envelope regions and its association with the immune response. Clonal sequences of the env C2V3C3 region were obtained from a cohort of eighteen HIV-2 chronically infected patients followed prospectively during 2-4 years. Genetic diversity, divergence, positive selection and glyc...
Emphysematous cholecystitis.
Freitas, L; Serviço de Doenças Infecciosas, Hospital de Santa Maria.; Do Carmo, G; Caldeira, L; Farto e Abreu, J; Lélis, M; Doroana, MEmphysematous cholecystitis (EC) is a rare and dramatic disease that requires prompt therapeutic procedures. The authors report a case of a 70-year-old-woman, admitted to the Intensive Care Unit for Infectious Diseases of the Santa Maria Hospital, with the diagnosis of EC. The literature on EC is also reviewed. ; Emphysematous cholecystitis (EC) is a rare and dramatic disease that requires prompt therapeutic p...
Cerebral toxoplasmosis in AIDS patients, CT and MRI images and differential dia...
Miguel, J; Serviço de Neurorradiologia e Anatomia-Patológica, Hospital Egas Moniz, Lisboa.; Champalimaud, J L; Borges, A; Chorão, M; Branco, GCranial computed-tomographies (CT) and magnetic resonance imaging (MRI) of 14 patients with AIDS and central nervous system toxoplasmosis (CNST) were reviewed. In spite of the low specificity of CT and MRI findings in CNS mass lesions of AIDS patients, there are some features which have been observed as more typical of CNST, namely: 94.9% of the lesions were round shaped and 94.5% had ring or nodular enhancemen...
Febrile coma and disseminated intravascular coagulation following heat stroke.
Lélis, M; Serviço de Doenças Infecto-Contagiosas, Hospital de Santa Maria, Lisboa.; do Carmo, G; Caldeira, L; Abreu, J; Freitas, L; Doroana, MA clinical case that occurred in a 42 years old female and which fulfils the diagnostic criteria for the entity described as Heat Stroke is presented. In this case, besides the usual manifestations of hyperpyrexia without sweating along with consciousness disorders, features of consumptive coagulopathy, rhabdomyolysis and well marked laboratory liver dysfunction have also been found. The severity of this situat...
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