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Association of FTO and PPARG polymorphisms with obesity in Portuguese women
Carlos, Fábio Ferreira; Silva-Nunes, José; Flores, Orfeu; Brito, Miguel; Doria, Gonçalo; Veiga, Luísa; Baptista, Pedro VianaPurpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. Patients and methods: A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥...
DNA nanoprobes for molecular detection
Doria, Gonçalo Maria Reimão Pinto de FrançaDissertação apresentada para obtenção do Grau de Doutor em Engenharia Biológica – especialidade Engenharia Genética, pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia ; The main objective of this thesis was to develop a simple and inexpensive method for nucleic acid detection in biological samples based on the colorimetric properties of gold nanoparticles. Gold nanoparticles were synthesized...
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