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Síndrome de Wolfram. A Propósito de Um Caso Clínico
Figueiredo, Ana Cristina; Pinto, Eduarda; Frutuoso, Simão; Dores, Jorge; Carvalho, Rui; Alves, ValterA síndrome de Wolfram, inicialmente descrita em 1938, caracteriza-se pela associação de Diabetes Mellitus, atrofia óptica e de forma mais inconstante surdez, Diabetes Insípida, alterações urinárias e neurológicas. Esta síndrome, frequentemente familiar, tem uma transmissão autossómica recessiva, tendo sido descrita recentemente uma ligação a marcadores no braço curto do cromossoma 4.Descreve-se o caso de uma me...
Insulinoterapia na diabetes mellitus tipo 2
Dores, JorgeType 2 diabetes is a growing prevalent disease, usually symptomless, with devastating chronic complications for the individual, family and society. Its progressive nature leads to the dose escalating and the association of different drugs which will rapidly become insufficient to achieve the glycemic goals established individually. Insulin is the most effective drug to control diabetes but there is frequently a...
Evaluation of diabetic foot amputation rate.
Horta, Cláudia; Vilaverde, Joana; Mendes, Paula; Gonçalves, Isabel; Serra, Luís; Pinto, Pedro Sá; Almeida, Rui; Carvalho, Rui; Dores, JorgeIn 1987, it was created the first portuguese Diabetic Foot Clinic in Oporto, at the Hospital Geral de Santo António. The distinction between neuropathic and ischaemic foot was the key stone to reduce drastically the rate of major amputations in the first two years of activity. Since then and until 1995 the rate of major amputations had stabilised around 8%. The aim of the present study was to evaluate if there ...
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