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Analysis of DNA damage and repair in Saccharomyces cerevisiae using the comet a...
Azevedo, F.; Marques, Filipe; Fokt, Hanna; Domingues, Alberta; Dias, Alberto Carlos Pires; Johansson, Björn; Oliveira, Rui Pedro Soares deIn this work we used the model organism Saccharomyces cerevisiae to characterise the biological activity and the mechanism of action of phytochemicals. We have assessed DNA damage and repair using the comet assay, which displayed a dose-response relationship with different DNA-damaging agents. Subsequently, we used this system to assess the antigenotoxic properties of a leaf extract from Ginkgo biloba (GBE). Ex...
Analysis of DNA damage and repair in saccharomyces cerevisiae using the comet a...
Azevedo, F.; Marques, Filipe; Fokt, Hanna; Domingues, Alberta; Dias, Alberto Carlos Pires; Johansson, Björn; Oliveira, Rui Pedro Soares deIn this work we used the model organism Saccharomyces cerevisiae to characterise the biological activity and the mechanism of action of phytochemicals. One of the goals is to use mutant strains affected in basic mechanisms of oxidative stress response and DNA repair in order to uncover the molecular targets of phytochemicals. We have assessed DNA damage and repair using the comet assay, evaluated as “comet tail...
Evaluation of antigenotoxic effects of phytochemicals : DNA protection from oxi...
Domingues, Alberta; Dias, Alberto Carlos Pires; Oliveira, Rui Pedro Soares deIn recent years, plant extracts and their phytochemicals have received increasing attention, especially in the field of pharmaceutical sciences and medicine, due to the potential prevention activity of a number of chronic and degenerative diseases including cancer and cardiovascular diseases. Most of the health-promoting effects have been attributed to antioxidant action including the ability to scavenge reacti...
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