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Evaluation of an orthotopically implanted calcium phosphate cement containing g...
Link, Dennis P.; Dolder, Juliette van den; Beucken, Jeroen J. J. P. van den; Habraken, Wouter; Soede, Annemieke; Boerman, Otto C.; Mikos, Antonios G.This study focused on the degradation properties of gelatin microparticles incorporated in calcium phosphate (CaP) cement and the subsequent effect of these composites on bone formation. Positively charged alkaline gelatin (type A) microparticles or negatively charged acidic gelatin (type B) microparticles were incorporated in CaP cement, which was implanted in critical-sized cranial defect in rats and left in ...
Bone response and mechanical strength of rabbit femoral defects filled with inj...
Link, Dennis P.; Van den Dolder, Juliette; Van den Beucken, Jeroen J.; Wolke, Joop G.; Mikos, Antonios G.; Jansen, John A.This study focused at the potential of transforming growth factor β1 (TGF-β1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites. Therefore, TGF-β1 loaded composites and non-loaded controls were injected in circular defects as created in the femoral condyles of rabbits and we...
The cytocompatibility and early osteogenic characteristics of an injectable cal...
Link, Dennis P.; Van den Dolder, Juliette; Van den Beucken, Jeroen J.; Jansen, John A.In this study, the cytocompatibility and early osteogenic characteristics of rat bone marrow cells (RBMCs) on injectable calcium phosphate (CaP) cement (Calcibon) were investigated. In addition to unmodified CaP cement discs, 2 other treatments were given to the discs: preincubation in MilliQ and sintering at different temperatures. After primary culture, RBMCs were dropwise seeded on the discs and cultured for...
Bone regenerative properties of injectable PGLA-CaP composite with TGF-beta1 in...
Plachokova, A.; Link, Dennis P.; Van den Dolder, Juliette; Van den Beucken, Jeroen J.; Jansen, John A.The aim of this study was to examine the bone augmentation properties of an injectable composite consisting of PLGA microspheres/CaP cement (20/80), and the additional effect of loading PLGA microspheres with TGF-β1 (200 ng). For this purpose, PLGA/CaP composites (control) and PLGA/CaP composites loaded with TGF-β1 (test group) were injected on top of the skulls of 24 Wistar rats. Each rat received 2 materials ...
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