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Controlled delivery achieved with bi-layer matrix devices produced by co-inject...
Vaz, Cláudia M.; Doeveren, P. F. N. M. van; Dias, Gustavo R.; Reis, R. L.; Cunha, A. M.The aim of this study was to design new soy protein-based bi-layered co-injection moulded matrix systems aimed to achieve controlled drug delivery. The devices consisted of a drug-free outer layer (skin) and a drug-containing core. The systems overcame the inherent disadvantage of non-linear release associated with diffusion-controlled single-layer matrix devices by providing additional releasing area with time...
Development and design of double-layer co-injection moulded soy protein based d...
Vaz, C. M.; Doeveren, P. F. N. M. van; Reis, R. L.; Cunha, A. M.Novel double-layer delivery devices based on soy protein derived materials were designed and produced using an innovative two material co-injection moulding technique. It was demonstrated that the viscosity ratio between core and skin layer materials played an important role in the formation of the interfacial shape, namely the skin thickness and uniformity of the bi-materials. The adequate selection of the mat...
Soy matrix drug delivery systems obteined by melt-processing techniques
Vaz, Cláudia M.; Doeveren, P. F. N. M. van; Reis, R. L.; Cunha, A. M.The aim of this study was to develop new soy protein drug delivery matrix systems by melt-processing techniques, namely, extrusion and injection moulding. The soy matrix systems with an encapsulated drug (theophylline, TH) were previously compounded by extrusion performed at two different pH values, (i) pH 4 (SIpDtp) and (ii) pH 7 (SIDtp), and further injection-moulded into a desired shape. During the extrusion...
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