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Pullulan-based nanoparticles as carriers for transmucosal protein delivery
Dionísio, Marita; Cordeiro, Clara; Remuñán-López, Carmen; Seijo, Begoña; Costa, Ana M. Rosa da; Grenha, AnaPolymeric nanoparticles have revealed very effective in transmucosal delivery of proteins. Polysaccharides are among the most used materials for the production of these carriers, owing to their structural flexibility and propensity to evidence biocompatibility and biodegradability. In parallel, there is a preference for the use of mild methods for their production, in order to prevent protein degradation, ensur...
Locust bean gum: exploring its potential for biopharmaceutical applications
Dionísio, Marita; Grenha, AnaPolysaccharides have been finding, in the last decades, very interesting and useful applications in the biomedical and, specifically, in the biopharmaceutical field. Locust bean gum is a polysaccharide belonging to the group of galactomannans, being extracted from the seeds of the carob tree (Ceratonia siliqua). This polymer displays a number of appealing characteristics for biopharmaceutical applications, amon...
Biocompatibility of chitosan carriers with application in drug delivery
Rodrigues, Susana; Dionísio, Marita; Remuñán-López, Carmen; Grenha, AnaChitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and micron-sized particles. In addition to its interesting physicochemical and biopharmaceutical properties, which include high mucoadhesion and a great capacity t...
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