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Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Ene...
Rossato, Luciana Grazziotin; Costa, Vera Marisa; Dallegrave, Eliane; Arbo, Marcelo; Silva, Renata; Ferreira, Rita; Amado, FranciscoMitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycles of 2.5 mg/kg MTX at day 0, 10, and 20. One treated group was euthanized on day 22 (MTX22) to evaluate the early...
Mephedrone (“Meow Meow”), The New Designer Drug of Abuse: Pharmacokinetics, Pha...
Ribeiro, Emanuel; Magalhães, Teresa; Dinis-Oliveira, Ricardo JorgeMephedrone is a semisynthetic derivative of cathinone used as a drug of abuse. Similar to amphetamine, both in chemical structure and associated symptoms, has gained popularity since 2007 and it is currently the sixth most popular drug among United Kingdom users. It can be easily purchased on the Internet or smart shops and it is more advantageous than ecstasy, given its higher purity and lower price. Mephedron...
Ethical, technical and legal procedures of the medical doctor responsibility to...
Dinis-Oliveira, Ricardo Jorge; Nunes, Rui; Carvalho, Félix; Santos, Agostinho; Teixeira, Helena; Vieira, Duarte Nuno; Magalhães, TeresaThe forensic toxicology (TF) is a science of analytical basis, aiming to clarify legal issues related to poisoning, whether or not fatal, within the various areas of law (criminal, civil, labor, etc.). The analysis that are more often requested (with a tendency to increase and gaining rising attention) are those concerning the procedures involving supervision of driving under the influence of alcohol and psycho...
Reactivity of paraquat with sodium salicylate: Formation of stable complexes
Dinis-Oliveira, Ricardo Jorge; Pinho, Paula Guedes de; Ferreira, Antonio César Silva; Silva, Artur M. S.; Afonso, Carlos; Bastos, Maria de LourdesSodium salicylate (NaSAL) has been shown to be a promising antidote for the treatment of paraquat (PQ) poisonings. The modulation of the pro-oxidant and pro-inflammatory pathways, as well as the antithrombogenic properties of NaSAL are probably essential features for the healing effects provided by this drug. Nevertheless, a possible direct chemical reactivity between PQ and NaSAL is also a putative pathway to ...
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