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Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smo...
Brito, Paula M.; Devillard, Raphaël; Nègre-Salvayre, Anne; Almeida, Leonor M.; Dinis, Teresa C. P.; Salvayre, Robert; Augé, Nathaliehttp://www.sciencedirect.com/science/article/B6T12-4V0MTG8-1/2/7b7f3913eea3a6f05047e8c1927696a9
Fast Three Dimensional Pharmacophore Virtual Screening of New Potent Non-Steroi...
Neves, Marco A. C.; Dinis, Teresa C. P.; Colombo, Giorgio; Melo, M. Luísa Sá eSuppression of estrogen biosynthesis by aromatase inhibition is an effective approach for the treatment of hormone sensitive breast cancer. Third generation non-steroid aromatase inhibitors have shown important benefits in recent clinical trials with postmenopausal women. In this study we have developed a new ligand-based strategy combining important pharmacophoric and structural features according to the postu...
Biochemical and computational insights into the anti-aromatase activity of natu...
Neves, Marco A. C.; Dinis, Teresa C. P.; Colombo, Giorgio; Melo, M. Luisa Sá eHigh levels of endogenous estrogens are associated with increased risks of breast cancer. Estrogen levels are mainly increased by the activity of the aromatase enzyme and reduced by oxidative/conjugative metabolic pathways. In this paper, we demonstrate for the first time that catechol estrogen metabolites are potent aromatase inhibitors, thus establishing a link between aromatase activity and the processes inv...
Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LD...
Bem, Andreza Fabro de; Farina, Marcelo; Portella, Rafael de Lima; Nogueira, Cristina Wayne; Dinis, Teresa C. P.; Laranjinha, João A. N.Oxidative modification of low-density lipoprotein (LDL) represents an important factor in atherogenesis. In the present study, we have investigated the antioxidant capability of diphenyl diselenide (PhSe)2, a simple organoseleno compound, against copper (Cu2+) and peroxyl radical-induced human LDL oxidation in vitro. In initial studies using human serum, (PhSe)2 caused a dose-dependent inhibition of Cu2+-induce...
Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a...
Brito, Paula; Simões, Núria; Almeida, Leonor; Dinis, TeresaAbstract Resveratrol (3,4',5-trihydroxystilbene) is a phytochemical believed to be partly responsible for the cardioprotective effects of red wine due to its numerous biological activities. Here, we studied biochemical pathways underlying peroxynitrite-mediated apoptosis in endothelial cells and potential mechanisms responsible for resveratrol cytoprotective action. Peroxynitrite triggered endothelial cell apo...
Combining Computational and Biochemical Studies for a Rationale on the Anti-Aro...
Neves, Marco A. C.; Dinis, Teresa C. P.; Colombo, Giorgio; Melo, M. Luísa Sá eAromatase, an enzyme of the cytochrome P450 family, is a very important pharmacological target, particularly for the treatment of breast cancer. The anti-aromatase activity of a set of natural polyphenolic compounds was evaluated in vitro. Strong aromatase inhibitors including flavones, flavanones, resveratrol, and oleuropein, with activities comparable to that of the reference anti-aromatase drug aminoglutethi...
Resveratrol affords protection against peroxynitrite-mediated endothelial cell ...
Brito, Paula M.; Mariano, Anabela; Almeida, Leonor M.; Dinis, Teresa C. P.Atherosclerosis, the main cause of cardiovascular disease (CD), is a chronic inflammatory condition associated with an overproduction of oxidant species, namely peroxynitrite, which is a powerful oxidant that reacts directly with all biomolecules. Glutathione is an efficient scavenger of peroxynitrite, so, modulation of glutathione synthesis may provide a strategy to selectively protect cells from this oxidant....
Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction...
Gonçalves, Cristina; Dinis, Teresa; Batista, Maria TeresaDecoctions prepared from the bark of Uncaria tomentosa (cat's claw) are widely used in the traditional Peruvian medicine for the treatment of several diseases, in particular as a potent anti-inflammatory agent. Therefore, the main purpose of this study was to determine if the well-known anti-inflammatory activity of cat's claw decoction was related with its reactivity with the oxidant species generated in the i...
Antioxidant activity of 5-aminosalicylic acid against lipid peroxidation in the...
Gonçalves, Elisabete; Almeida, Leonor M.; Dinis, Teresa C. P.It is now recognized that the antioxidant defences in the colonic mucosa from patients with inflammatory bowel disease (IBD) are particularly low. On account of this we studied the antioxidant capacity of 5-ASA, the first choice therapy in this pathological situation, in combination with the endogenous antioxidants vitamins C (ASC) and E ([alpha]-tocopherol ([alpha]-T)) against lipid peroxidation in phosphatidy...
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