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Evaluation of the structure–activity relationship of thrombin with thrombin bin...
Diculescu, Victor Constantin; Chiorcea-Paquim, Ana-Maria; Eritja, Ramon; Oliveira-Brett, Ana MariaThe structure–activity relationship of the complex between thrombin and thrombin binding aptamers (TBA) was evaluated by differential pulse voltammetry at a glassy carbon electrode and atomic force microscopy at a highly oriented pyrolytic graphite electrode. The effects on the interaction with thrombin of TBA primary and secondary structures as well as of its folding properties in the presence of alkaline meta...
Metallo-functionalized first-generation salicylaldimine poly(propylenimine) tet...
Martinovic, Jasmina; Chiorcea-Paquim, Ana-Maria; Diculescu, Victor Constantin; Wyk, Juanita Van; Iwuoha, Emmanuel; Baker, Priscilla; Mapolie, SelwynThe adsorption and the redox processes of two first-generation salicylaldiamine dendritic ligands and their copper, cobalt and nickel metallo-functionalized complexes have been studied at two types of carbon electrode surface. Glassy carbon (GC) was used in an electrochemistry study and highly oriented pyrolitic graphite (HOPG) in ex situ atomic force microscopy (AFM) imaging. All salicylaldimine ligands and th...
Poly(glutamic acid) nanofibre modified glassy carbon electrode: Characterizatio...
Santos, Daniela Pereira; Zanoni, Maria Valnice Boldrin; Bergamini, Márcio Fernando; Chiorcea-Paquim, Ana-Maria; Diculescu, Victor ConstantinGlassy carbon electrodes (GCE) were modified with poly(glutamic acid) acid films prepared using three different procedures: glutamic acid monomer electropolymerization (MONO), evaporation of poly(glutamic acid) (PAG) and evaporation of a mixture of poly(glutamic acid)/glutaraldehyde (PAG/GLU). All three films showed good adherence to the electrode surface. The performance of the modified GCE was investigated by...
Voltammetric Behavior of Antileukemia Drug Glivec. Part III: In Situ DNA Oxidat...
Diculescu, Victor Constantin; Vivan, Marilene; Brett, Ana Maria OliveiraGlivec is a relatively small molecule with activity against the protein tyrosine kinase, a protein expressed by all patients with chronic myelogenous leukemia (CML). Based on its activity on CML, glivec is undergoing extensive evaluation of its activity against other types of tumor. As a result, there is an ongoing need for clarification of glivec pharmacokinetics so that issues such as drug-biomolecular comple...
Voltammetric Behavior of Antileukemia Drug Glivec. Part II - Redox Processes of...
Diculescu, Victor Constantin; Vivan, Marilene; Brett, Ana Maria OliveiraGlivec is a newly developed drug that belongs to the class of 2-phenylaminopyrimidine. It is a potent inhibitor of ABL-kinase, the main clinical manifestation of chronic myelogenous leukemia (CML). Based on its activity on CML, glivec is undergoing extensive evaluation for its activity against other tumor types. Detection and quantitation of glivec in biological fluids or cells is thus very important. The antil...
Voltammetric Behavior of Antileukemia Drug Glivec. Part I - Electrochemical Stu...
Diculescu, Victor Constantin; Vivan, Marilene; Brett, Ana Maria OliveiraThe electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH-dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, Pglivec, which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of Pglivec at the GCE surf...
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