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Electrochemical oxidation of ochratoxin A at a glassy carbon electrode and in s...
Oliveira, S. C. B.; Diculescu, V. C.; Palleschi, G.; Compagnone, D.; Oliveira-Brett, A. M.Ochratoxin A (OTA) is a fungal metabolite that occurs in foods, beverages, animal tissues, human blood and presents carcinogenic, teratogenic and nephrotoxic properties. This study concerns the redox properties of OTA using electrochemical techniques which have the potential for providing insights into the biological redox reactions of this molecule. The in situ evaluation of the OTA interaction with DNA using ...
Electrochemistry of nanoscale DNA surface films on carbon
Oliveira-Brett, A. M.; Paquim, A. M. Chiorcea; Diculescu, V. C.; Piedade, J. A. P.A DNA electrochemical biosensor is an integrated receptor-transducer device. The most important step in the development and manufacture of a sensitive DNA-biosensor for the detection of DNA-drug interactions is the immobilization procedure of the nucleic acid probe on the transducer surface. Magnetic A/C Mode atomic force microscopy (MAC Mode AFM) images in air were used to characterize two different procedures...
AFM and electroanalytical studies of synthetic oligonucleotide hybridization
Paquim, A. -M. Chiorcea; Diculescu, V. C.; Oretskaya, T. S.; Brett, A. M. OliveiraThe first and most important step in the development and manufacture of a sensitive DNA-biosensor for hybridization detection is the immobilization procedure of the nucleic acid probe on the transducer surface, maintaining its mobility and conformational flexibility. MAC Mode AFM images were used to demonstrate that oligonucleotide (ODN) molecules adsorb spontaneously at the electrode surface. After adsorption,...
Voltammetric determination of all DNA nucleotides
Oliveira-Brett, A. M.; Piedade, J. A. P.; Silva, L. A.; Diculescu, V. C.The voltammetric oxidation of all deoxyribonucleic acid (DNA) monophosphate nucleotides is investigated for the first time over a wide pH range by differential pulse voltammetry with a glassy carbon electrode. Experimental conditions such as the electrode size, supporting electrolyte composition, and pH were optimized to obtain the best peak potential separation and higher currents. This enabled the simultaneou...
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