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Enxertos e substitutos ósseos em cirurgia ortopédica reconstrutiva nos animais ...

We present here an overview of the scientific literature concerning the clinical application of autografts and allografts of the skeletal tissues and of the natural and synthetic bone graft substitutes available in small animal orthopedic surgery for resolution of congenital, traumatic and tumoral etiology situations or for reconstructive artroplastic surgeries. This article focuses the terminology, definitions...

Translating human adipose-derived stem cells (hASCs) to clinical practice requi...

Biological evaluation of intervertebral disc cells in different formulations of...

Gellan gum (GG)-based hydrogels are advantageous in tissue engineering not only due to their ability to retain large quantities of water and provide a similar environment to that of natural extracellular matrix (ECM), but also because they can gelify in situ in seconds. Their mechanical properties can be fine-tuned to mimic natural tissues such as the nucleus pulposus (NP). This study produced different formula...

Synergistic effect of scaffold composition and dynamic culturing environment in...

Bone extracellular matrix (ECM) is composed of mineralized collagen fibrils which support biological apatite nucleation that participates in bone outstanding properties. Understanding and mimicking bone morphological and physiological parameters at a biological scale is a major challenge in tissue engineering scaffolding. Using emergent (nano)technologies scaffold designing may be critically improved, enabling ...

Tissue engineered constructs based on SPCL scaffolds cultured with goat marrow ...

This study aims to assess the in vivo performance of cell–scaffold constructs composed of goat marrow stromal cells (GBMCs) and SPCL (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. GBMCs from iliac crests were seeded onto SPCL scaffolds and in vitro cultured for 1 and 7 days in osteogenic medium. After 1 and 7 days, the constructs wer...

In vitro and in vivo biocompatibility evaluation of k-carrageenan hydrogels aim...

Introduction The development of biomaterials for biomedical applications always requires extensive biological testing to demonstrate the safety of both the material and its degradation components. K-carrageenan is a naturally occurring polysaccharide which forms a hydrogel with potassium ions and the temperature-induced gelation enables its application as an in vitro cell-carrier or as an in vivo injectable sys...

Effect of flow perfusion conditions in the chondrogenic differentiation of bone...

Cartilage tissue engineering (TE) typically involves the combination of a 3-D biodegradable polymeric support material, with primary chondrocytes or other cell types able to differentiate into chondrocytes. The culture environment in which cell–material constructs are created and stored is an important factor. Various bioreactors have been introduced in TE approaches to provide specific culturing environments t...

Evaluation of biomarkers of bone formation and serum minerals variations for pr...

Evaluation of bone fracture healing by biochemical markers of bone metabolism

Evaluation of fracture healing process in dog by tartrate-resistant acid phosph...