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The role of glycoprotein 130 family of cytokines in fetal rat lung development
Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Veiga, Carla; Moura, Rute S.; Pinto, Jorge CorreiaThe glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and oncostatin M (OSM). These cytokines share the membrane gp130 as a common signal transducer. Recently, it was demonstrated that IL-6 promotes, whereas LIF inhibits fetal lung branching...
Local fetal lung renin-angiotensin system as a target to treat congenital diaph...
Silva, Cristina Nogueira; Dias, Emanuel Carvalho; Piairo, Paulina C.; Nunes, Susana; Baptista, Maria João Ribeiro Leite; Moura, Rute S.Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1)...
Leukemia inhibitory factor in rat fetal lung development : expression and funct...
Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Peixoto, Francisca; Moura, Rute S.; Pinto, Jorge CorreiaConceived and designed the experiments: CN-S EC-D JC-P. Performed the experiments: CN-S PP EC-D FOP RSM. Analyzed the data: CN-S PP JC-P. Wrote the paper: CN-S PP RSM JC-P. ; Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are members of the family of the glycoprotein 130 (gp130)-type cytokines. These cytokines share gp130 as a common signal transducer, which explains why they show some functional re...
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