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Irf4 is a positional and functional candidate gene for the control of serum IgM...
Côrte-Real, J; Rodo, Joana; Almeida, P; Coutinho, António; Demengeot, Jocelyne; Penha-Gonçalves, CarlosNatural IgM are involved in numerous immunological functions but the genetic factors that control the homeostasis of its secretion and upholding remain unknown. Prompted by the finding that C57BL/6 mice had significantly lower serum levels of IgM when compared with BALB/c mice, we performed a genome-wide screen and found that the level of serum IgM was controlled by a QTL on chromosome 13 reaching the highest l...
Protection against systemic candidiasis in mice immunized with secreted asparti...
Vilanova, Manuel; Teixeira, Luzia; Caramalho, Íris; Torrado, Egídio; Marques, Andreia; Madureira, Pedro; Ribeiro, Adília; Ferreira, Paula; Gama, F. M.Secreted aspartic proteinases (Sap) have been described as virulence factors implicated in the mechanisms of host colonization by the yeast Candida albicans in different types of candidiasis. Intraperitoneal inoculation of C. albicans into BALB/c mice rapidly leads to systemic candidiasis, with significant colonization of the kidneys measurable in the following week. In this study we assessed the potential of v...
Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleu...
Carvalho, Thiago L.; Mota-Santos, Tomaz; Cumano, Ana; Demengeot, Jocelyne; Paulo, VieiraInterleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1 and marginal zone (MZ) compart...
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