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Transthyretin is involved in depression-like behaviour and exploratory activity
Sousa, João Carlos; Grandela, Catarina; Fernández-Ruiz, Javier; Miguel, Rosário de; Sousa, Liliana de; Magalhães, Ana Isabel; Saraiva, Maria JoãoTransthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the per...
Epidemiology of craniocerebral trauma in Portugal.
Santos, Maria Emília; De Sousa, Liliana; Castro-Caldas, AlexandreThe epidemiology of traumatic brain injury (TBI) was studied in Portugal, using data of hospital admissions and total mortality, in 1994, 1996 and 1997. A rate of incidence of 151/100,000 for 1994 and of 137/100,000, for 1996 and 1997, was observed. Although in the last two years the incidence was the same, the mortality has decreased. The global rate of mortality for 1997 was of 17/100,000, with highest risk i...
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