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Biocatalyzed Generation of Molecular Diversity: Selective Modification of the S...
Monti, Daniela; Candido, Andrea; Cruz Silva, M. Manuel; Kren, Vladimir; Riva, Sergio; Danieli, BrunoAn array of different derivatives of the complex ursane-type triterpene glycoside asiaticoside (1), a saponin component isolated from the perennial herb Centella asiatica, was generated by exploiting the stereo-, regio- and site-selectivity of four groups of enzymes (glycosidases, glycosyltransferases, lipases and laccases). A library of extracellular alpha-L-rhamnosidases (31 different items) was obtained by s...
The biocatalyzed stereoselective preparation of polycyclic cyanohydrins
Silva, M. Manuel Cruz; Melo, M. Luísa Sá e; Parolin, Marco; Tessaro, Davide; Riva, Sergio; Danieli, BrunoThe enzyme-mediated preparation of enantiomerically or diastereomerically enriched polycyclic cyanohydrins has been investigated. Oxynitrilase-catalyzed cyanurations gave excellent results with the bicyclic aldehydes tested. On the other hand, enantio- or diastereoselective acylation, catalyzed by lipase PS or subtilisin, proved to be a more versatile methodology, giving good results even with sterically hinder...
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