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Microtubule-associated protein tau is essential for long-term depression in the...

The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hip...

A Quem estamos ligados? Perfil de utilização do contacto móvel de uma Unidade ...

Particularidades de um modelo de acompanhamento de enlutados em contexto de in...

Epigenetic and transcriptional signatures of stable versus plastic differentiat...

Two distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) γδ T cells) or interferon-γ (IFN-γ) (CD27(+) γδ T cells) develop in the mouse thymus, but the molecular determinants of their functional potential in the periphery remain unknown. Here we conducted a genome-wide characterization of the methylation patterns of histone H3, along with analysis of mRNA encoding transcription factors, to...

Drilling delamination outcomes on glass and sisal reinforced plastics

Nowadays, fibre reinforced plastics are used in a wide variety of applications. Apart from the most known reinforcement fibres, like glass or carbon, natural fibres can be seen as an economical alternative. However, some mistrust is yet limiting the use of such materials, being one of the main reasons the inconsistency normally found in their mechanical properties. It should be noticed that these materials are ...

Damage evaluation of drilled carbon/epoxy laminates based on area assessment me...

The characteristics of carbon fibre reinforced laminates had widened their use, from aerospace to domestic appliances. A common characteristic is the need of drilling for assembly purposes. It is known that a drilling process that reduces the drill thrust force can decrease the risk of delamination. In this work, delamination assessment methods based on radiographic data are compared and correlated with mechani...

Dano na furação de placas carbono/epóxido

A produção de peças estruturais em materiais compósitos, nomeadamente os de matriz epóxida reforçada com fibras de carbono, tem-se tornado cada vez mais importante face à combinação das suas características específicas, como elevada rigidez e o baixo peso. Embora por um lado o custo destes materiais tenha vindo a tornar-se numa barreira cada vez menor para a sua utilização, a necessidade de operações de acabame...

Modelação da furação de laminados por elementos finitos

Furação de estruturas em compósitos de matriz polimérica ; O recurso ao Método de Elementos Finitos (MEF) para a simulação e estudo da maquinagem tem vindo a merecer um interesse crescente. Neste trabalho comparam-se os resultados experimentais obtidos usando diferentes brocas helicoidais com uma simulação numérica da furação usando elementos sólidos tridimensionais do software ABAQUS® Explicit. Os resultados ...

Comparative analysis of drills for composite laminates

The characteristics of carbon fiber-reinforced plastics allow a very broad range of uses. Drilling is often necessary to assemble different components, but this can lead to various forms of damage, such as delamination which is the most severe. However, a reduced thrust force can decrease the risk of delamination. In this work, two variables of the drilling process were compared: tool material and geometry, as ...

Damage evaluation of drilled carbon/epoxy laminates based on area assessment me...

The characteristics of carbon fibre reinforced laminates had widened their use, from aerospace to domestic appliances. A common characteristic is the need of drilling for assembly purposes. It is known that a drilling process that reduces the drill thrust force can decrease the risk of delamination. In this work, delamination assessment methods based on radiographic data are compared and correlated with mechani...