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Downregulation of RKIP is associated with poor outcome and malignant progressio...
Martinho, Olga; Granja, Sara Costa; Jaraquemada, Teresa; Caeiro, Cláudia; Gonçalves, Vera M.; Honavar, Mrinalini; Costa, Paulo; Damasceno, MargaridaMalignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis ...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...
Guidelines for prevention of febrile neutropenia.
Barroso, Sérgio; Damasceno, Margarida; Dinis, José; Gervásio, Helena; da Luz, Ricardo; Passos-Coelho, J L; Sá, Anabela; Costa, Luís; Rodrigues, HelenaNeutropenia and febrile neutropenia are common consequences of some cytotoxic chemotherapy regimens. This situation leads to modifications of the therapeutic regimen, conducting to either dose reduction or cycle delays. Granulocyte colony stimulating factors are commonly used to minimize chemotherapy cytotoxic effect on the granulocytic series. The objective of this study is to assess the available evidence in ...
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