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The association of p16INK4A and fragile histidine triad gene expression and cer...
Longatto Filho, Adhemar; Etlinger, Daniela; Pereira, Sónia Maria Miranda; Kanamura, Cristina Takami; Loreto, Celso di; Santos, Gilda da CunhaObjective. This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16INK4A and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions. Materials and Methods. Women seen at Pe´ rola Byington Hospital, São Paulo, Brazil, with histologically confirmed cervicitis (n = 31), cervical intraepithelial neoplasia (CIN) 1 (n = 30), CIN 2,3 (n = 3...
Performance of the DNA-citoliq liquid-based cytology system compared with conve...
Alves, Venâncio Avancini Ferreira; Castelo, A.; Filho, A. L.; Vianna, M. R.; Taromaru, Eliane; Namiyama, Gislene; Lörincz, A.; Dôres, Gerson B. dasTo evaluate the performance of a new, manual, simplified liquid-based system, DNA-Citoliq (Digene Brasil), employed under routine conditions as compared to conventional smears collected from six collaborating private laboratories. Methods: A panel of cytopathologists, who served as the gold standard diagnosis, adjudicated discordant opinions. Results: Of 3206 pairs of slides considered valid for comparison, the...
Screening for cervical Cancer in high-risk populations : DNA pap test or hybrid...
Pereira, Sónia Maria Miranda; Castelo, A.; Makabe, Sérgio; Utagawa, Maria Lúcia; Loreto, Celso di; Maeda, Marina Yoshiê Sakamoto; Marques, José A.This study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq LBC system. Women with suspected cervical disease were included in this crosssectional study at a tertiary center in São Paulo, Brazil, for further workup. All women had cervi...
Human papillomavirus testing as an optional screening tool in low-resource sett...
Longatto Filho, Adhemar; Eržen, M.; Branca, M.; Roteli-Martins, C.; Naud, P.; Derchain, S. F.; Hammes, L.; Sarian, L. O.; Bragança, J. F.; Matos, J. C.Hybrid capture II (HC II) test for oncogenic human papillomaviruses (HPV) was carried out in a cohort of 4284 women at their first clinical visit. Overall prevalence of HPV was 17.1%, decreasing with age from 33.9% among women below 20 years to only 11.0% among those older than 41 years. HPV prevalence was significantly higher among current smokers (odds ratio [OR] ¼ 1.31; 95% CI 1.1–1.6), in women with two or ...
Determinação da infecção do papilomavírus humano por captura híbrida II : corre...
Dôres, Gerson B. das; Bonomi, Cristiane G.; Longatto Filho, Adhemar; Gilli, Nilcisa P.; Matsubara, Shigueo; Focchi, José; Taromaru, ElianeO HPV é causa essencial, mas não suficiente, para o desenvolvimento de lesões pré-neoplásicas e neoplásicas do colo uterino. Sua identificação é fundamental para a avaliação de risco, sendo que o método de Captura Híbrida® apresenta reconhecida eficácia para esse fim. Por sua vez, os métodos morfológicos, colposcopia, citologia e histopatologia, demonstram as alterações celulares e tissulares sugestivas da ação...
Sistema DNA-Citoliq (DCS) : um novo sistema para citologia em base líquida : as...
Longatto Filho, Adhemar; Namiyama, Gislene; Castelo Filho, Adauto; Viann, Maria Regina; Dôres, Gerson B. das; Taromaru, ElianeIntroduction: DCS is a new liquid-base cytology system for cell collected in UCM. Objective: assess technical aspects of DCS under different pro-tocols. Methods: the first experiment was performed with 144 samples. After cervical scraping with Ayre spatula and endocervical brushing, the sample was immediately smeared on the slide and alcohol-fixed. The same brush with residual cells was used to scrap the ectoce...
Evaluation of visual inspection with acetic acid (VIA), Lugol’s iodine (VILI), ...
Sarian, L. O.; Derchain, S. F.; Naud, P.; Roteli-Martins, C.; Longatto Filho, Adhemar; Tatti, S.; Branca, M.; Dôres, Gerson B. das; Costa, S.Objectives: To assess the performance indicators of visual inspection with acetic acid (VIA) and visual inspection with Lugol’s iodine (VILI) in four Latin American centres participating in the ongoing Latin AMerican Screening (LAMS) study, in settings with moderate incidence of cervical disease and with poorly to moderately well-organized cervical cancer screening. Setting: Three Brazilian centres (São Paulo, ...
Human Papillomavirus prevalence, viral load and cervical intraepithelial neopla...
Levi,José E.; Fink,Maria C.S.; Canto,Cynthia L.M.; Carretiero,Nadily; Matsubara,Regina; Linhares,Iara; Dores,Gérson B. das; Castelo,AdautoHIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD4+ cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women ...
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