Encontrados 24 documentos, a visualizar página 1 de 3
Prevalence of bovine tuberculosis and risk factor assessment in cattle in rural...
Moiane, Ivânia; Machado, Adelina; Santos, Nuno M. S.; Nhambir, André; Inlamea, Osvaldo; Hattendorf, Jan; Källenius, Gunilla; Zinsstag, JakobBACKGROUND: Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is an infectious disease of cattle that also affects other domestic animals, free-ranging and farmed wildlife, and also humans. In Mozambique, scattered surveys have reported a wide variation of bTB prevalence rates in cattle from different regions. Due to direct economic repercussions on livestock and indirect consequences for human health a...
Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina; Pinto, Vítor; Mesquita, Sandro; Novais, Ashley da Cruz; Sousa, João Carlos; Neves, Margarida Correia; Sousa, NunoLipocalin-2 is involved in emotional behaviors and cognitive function ; Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display a...
Poor immune reconstitution in HIV-infected patients associates with high percen...
Horta, Ana; Nóbrega, Cláudia; Machado, Pedro Amorim; Teixeira, Vítor Emanuel Coutinho; Silva, Palmira Barreira; Boavida, Susana; Costa, Patrício SoaresCD4(+) regulatory T cells (Tregs) are essential for the maintenance of the immune system's equilibrium, by dampening the activation of potential auto-reactive T cells and avoiding excessive immune activation. To correctly perform their function, Tregs must be maintained at the right proportion with respect to effector T cells. Since this equilibrium is frequently disrupted in individuals infected with the human...
T Cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio; Rodrigues, Bruno Cerqueira; Roque, Susana; Silva, Palmira Barreira; Behar, Samuel M.; Neves, Margarida CorreiaThe thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
T cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio Nunes; Rodrigues, Bruno Miguel Cerqueira; Roque, Susana; Silva, Palmira Barreira da; Behar, Samuel M.The thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
Animal welfare in studies on murine tuberculosis : assessing progress over a 12...
Franco, Nuno; Neves, Margarida Correia; Olsson, AnnaThere is growing concern over the welfare of animals used in research, in particular when these animals develop pathology. The present study aims to identify the main sources of animal distress and to assess the possible implementation of refinement measures in experimental infection research, using mouse models of tuberculosis (TB) as a case study. This choice is based on the historical relevance of mouse stud...
A walk into the luxR regulators of actinobacteria : phylogenomic distribution a...
Santos, Catarina lopes; Mendes, Marta Vaz; Ferreira, Pedro Moradas; Neves, Margarida CorreiaLuxR regulators are a widely studied group of bacterial helix-turn-helix (HTH) transcription factors involved in the regulation of many genes coding for important traits at an ecological and medical level. This regulatory family is particularly known by their involvement in quorum-sensing (QS) mechanisms, i.e., in the bacterial ability to communicate through the synthesis and binding of molecular signals. Howev...
Neutrophils and macrophages : the main partners of phagocyte cell systems
Silva, Manuel T.; Neves, Margarida CorreiaBiological cellular systems are groups of cells sharing a set of characteristics, mainly key function and origin. Phagocytes are crucial in the host defense against microbial infection. The previously proposed phagocyte cell systems including the most recent and presently prevailing one, the mononuclear phagocyte system (MPS), grouped mononuclear cells but excluded neutrophils, creating an unacceptable situatio...
How “humane” is your endpoint? — Refining the science-driven approach for termi...
Franco, Nuno; Neves, Margarida Correia; Olsson, AnnaPublic concern on issues such as animal welfare or the scientific validity and clinical value of animal research is growing, resulting in increasing regulatory demands for animal research. Abiding to the most stringent animal welfare standards, while having scientific objectives as the main priority, is often challenging. To do so, endpoints of studies involving severe, progressive diseases need to be establish...
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of...
Mesquita, Sandro; Ferreira, A. C.; Sousa, João Carlos; Santos, Nadine Correia; Neves, Margarida Correia; Sousa, Nuno; Palha, Joana AlmeidaIron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach...
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