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Hydrogen peroxide sensing, signaling and regulation of transcription factors
Marinho, H. Susana; Real, Carla; Cyrne, Luísa; Soares, Helena; Antunes, FernandoThe regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-κB, NOTCH, SP1 and SCREB-1) are reviewed. The complexity of regulatory networks increases throughout the phylogenetic tree, reaching a high level of complexity in mammal...
Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveal...
Guerreiro, Paulo; Barreiros, Tânia; Soares, Helena; Cyrne, Luísa; Maia e Silva, Alexandra; Rodrigues-Pousada, ClaudinaA 17.6 kb DNA fragment from the right arm of chromosome VII of Saccharomyces cerevisiae has been sequenced and analysed. The sequence contains twelve open reading frames (ORFs) longer than 100 amino acids. Three genes had already been cloned and sequenced: CCT, ADE3 and TR-I. Two ORFs are similar to other yeast genes: G7722 with the YAL023 (PMT2) and PMT1 genes, encoding two integral membrane proteins, and G772...
The Tetrahymena chaperonin subunit CCT eta gene is coexpressed with CCT gamma g...
Cyrne, Luísa; Guerreiro, Paulo; Cardoso, Ana Cristina; Rodrigues-Pousada, Claudina; Soares, HelenaWe report here the cloning and the characterization of the T. pyriformis CCT eta gene (TpCCT eta) and also a partial sequence of the corresponding T. thermophila gene (TtCCT eta). The TpCCt eta gene encodes a protein sharing a 60.3% identity with the mouse CCT eta. We have studied the expression of these genes in Tetrahymena exponentially growing cells, cells regenerating their cilia for different periods and d...
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