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Quality control of gene expression in the mammalian cell nucleus

Tese de doutoramento em Ciências Biomédicas (Ciências Morfológicas) apresentada à Universidade de Lisboa através da Faculdade de Medicina, 2008 ; Protein-encoding genes are transcribed in the nucleus by RNA polymerase II as precursor RNAs that undergo extensive processing before being translocated to the cytoplasm for translation by the ribosomes. This spatial and temporal separation between RNA and protein sy...