Encontrados 3 documentos, a visualizar página 1 de 1
Hydroxytamoxifen interaction with human erythrocyte membrane and induction of p...
Cruz Silva, M. M.; Madeira, V. M. C.; Almeida, L. M.; Custódio, J. B. A.4-Hydroxytamoxifen (OHTAM) is the most active metabolite of the widely prescribed anticancer drug tamoxifen (TAM) used in breast cancer therapy. This work describes the effects of OHTAM on isolated human erythrocytes, using standardized test conditions, to check for a putative contribution to the TAM-induced hemolysis and to study basic mechanisms involved in the interaction of OHTAM with cell membranes. Incuba...
Mitochondrial permeability transition induced by the anticancer drug etoposide
Custódio, J. B. A.; Cardoso, C. M. P.; Madeira, V. M. C.; Almeida, L. M.Etoposide (VP-16) is widely used for the treatment of several forms of cancer. The cytotoxicity of VP-16 has been assigned to the induction of apoptotic cell death but the signaling pathway for VP-16-induced apoptosis is essentially unknown. There is some evidence that this process depends on events associated with the loss of mitochondrial membrane potential ([Delta][Psi]) and/or release of apoptogenic factors...
Toxic effects of tamoxifen on the growth and respiratory activity of Bacillus s...
Luxo, C.; Jurado, A. S.; Custódio, J. B. A.; Madeira, V. M. C.The anticancer drug tamoxifen (TAM) is used as first line therapy in breast cancer. Although tamoxifen is usually considered an estrogen antagonist, several studies suggest alternative mechanisms of action. Bacillus stearothermophilus has been used as a model to clarify the antiproliferative action of tamoxifen putatively related with drug-membrane interaction. According to previous data, TAM induces perturbati...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||