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Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and charac...
Teixeira, Fátima C.; Antunes, Inês F.; Curto, M. João M.; Neves, M.; Teixeira, António P. S.Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain wit...
Data: 2009
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Origem: Repositório Científico da Universidade de Évora
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