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Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?
Caldeira, Margarida V.; Salazar, Ivan L.; Cursio, Michele; Canzoniero, Lorella M. T.; Duarte, Carlos B.The ubiquitin–proteasome system (UPS) is a catalytic machinery that targets numerous cellular proteins for degradation, thus being essential to control a wide range of basic cellular processes and cell survival. Degradation of intracellular proteins via the UPS is a tightly regulated process initiated by tagging a target protein with a specific ubiquitin chain. Neurons are particularly vulnerable to any change ...
Data: 2014
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Origem: Estudo Geral - Universidade de Coimbra
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