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Optical coherence tomography: automatic retina classification through support v...

Optical coherence tomography (OCT) is becoming one of the most important imaging modalities in ophthalmology due to its non-invasiveness and by allowing the visualisation the human retina structure in detail. It was recently proposed that OCT data embeds functional information from the human retina. Specifically, it was proposed that blood–retinal barrier status information is present within OCT data from the h...

Noninvasive evaluation of retinal leakage using optical coherence tomography

Purpose: To demonstrate the association between changes in the blood-retinal barrier (BRB) identified by fluorescein leakage and those in the optical properties of the human retina determined by optical coherence tomography (OCT) and show how these changes can be quantified and their location identified within the retina. Methods: Two imaging techniques were applied: the retinal leakage analyzer, to map BRB fun...

Improved adaptive complex diffusion despeckling filter

Despeckling optical coherence tomograms from the human retina is a fundamental step to a better diagnosis or as a preprocessing stage for retinal layer segmentation. Both of these applications are particularly important in monitoring the progression of retinal disorders. In this study we propose a new formulation for a well-known nonlinear complex diffusion filter. A regularization factor is now made to be depe...

Inducible nitric oxide synthase isoform is a key mediator of leukostasis and bl...

PURPOSE: Nitric oxide (NO) is involved in leukostasis and blood-retinal barrier (BRB) breakdown in the early stages of diabetic retinopathy (DR), but it is unclear which NO synthase (NOS) isoforms are primarily involved. In this study, the authors aimed to clarify the involvement of constitutive (eNOS, nNOS) and inducible NOS (iNOS) isoforms and the mechanisms underlying NO-mediated leukostasis and BRB breakdow...

Single nucleotide polymorphism 10c/t of the pkc beta1 gene and diabetic retinop...

Nonproliferative retinopathy in diabetes type 2. Initial stages and characteriz...

This review addresses the initial stages of nonproliferative diabetic retinopathy in diabetes type 2. ; http://www.sciencedirect.com/science/article/B6TBT-4F1W6T6-1/1/dec451a0b9d54c244324296ec9426f6e

Macular alterations after small-incision cataract surgery

Purpose: To characterize macular edema that occurs after uneventful cataract surgery. ; http://www.sciencedirect.com/science/article/B6VSF-4C54BTG-N/1/fba2fd923592d5172c5e0a4f69426a61

Stabilization of visual acuity with photodynamic therapy in eyes with chorioret...

Purpose(1) To evaluate, in a non-randomized, institutional, prospective study, the efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomoses (CRA). (2) To review, in a retrospective study and for comparison, the natural evolution of neovascular AMD eyes with CRA.MethodsProspective clinical and angiographic study of 17 consecuti...

Alterations of retinal capillary blood flow in preclinical retinopathy in subje...

Background: To identify alterations of retinal capillary blood flow in the papillomacular area in preclinical diabetic retinopathy using the Heidelberg scanning laser Doppler flowmeter. Methods: Ten eyes from ten patients with type 2 diabetes and no lesions visible on fundus photography (level 10 of Wisconsin grading) and ten eyes from ten healthy subjects of similar age range were examined with the HRF. Intrav...

Effect of cyclosporin-A on the blood-retinal barrier permeability in streptozot...

BACKGROUND: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1beta (IL-1beta). This cytokine may be involved in the expression of the inducible isoform of the nitric oxide synthase (iNOS), with consequent synthesis of large amounts of NO and blood-retinal barrier (BRB) breakdown. AIMS: The aim of this work was to examine wheth...