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New developments in OCT evaluations
Bernardes, R.; Cunha-Vaz, J.Diabetic macular edema (DME) is one of the most common causes for visual loss (Ciulla et al., Diabetes Care, 2003). DME is characterized by an abnormal increase of the retinal thickness (RT) due to the accumulation of liquids in the retinal tissue, consequence of the first response to the inflammatory process occurring in diabetic retinopathy (DR). It is therefore considered one of the most important indicators...
Risk markers for progression of mild nonproliferative retinopathy to clinically...
Pereira, I.; Nunes, S.; Ribeiro, M. L.; Bernardes, R.; Cunha-Vaz, J.Purpose To determine risk markers for the development of clinically significant macular edema (CSME) needing photocoagulation treatment in type 2 diabetic patients with mild nonproliferative retinopathy (NPDR), during a 7-year period. Methods Fifty-one type 2 diabetic patients with mild NPDR, followed-up for 2 years as controls of diabetic retinopathy clinical trials, were selected. Patients underwent ophthalmo...
Diabetic macular edema. Clinical characterization
Cunha-Vaz, J.The most frequent cause of progressive visual loss due to diabetes is diabetic macular edema. There is retinal edema when there is any increase of water in the retinal tissue resulting in an increase in its volume, i.e., thickness. In diabetes, the inner Blood-Retinal Barrier (BRB) opens resulting in increasing movements of fluids and molecules into the retina. In a situation of open BRB there is extracellular ...
Calcium dobesilate prevents changes in tight junction proteins in the retina in...
Leal, E. C.; Martins, J.; Chiavaroli, C.; Cunha-Vaz, J.; Ambrósio, A. F.Purpose Calcium dobesilate has been found to correct the excessive vascular permeability associated with diabetes in the retina of diabetic patients and in experimental diabetes. However, the molecular mechanisms underlying these effects are not elucidated yet. In this study, we investigated the potential protective effect of calcium dobesilate against changes in tight junction proteins (occludin, ZO-1 and clau...
Retinal thickness vs. retinal sensitivity at the central human macula
Bernardes, R.; Cunha-Vaz, J.Purpose To assess the detailed correlation between retinal thickness and retinal visual function in the central 300 µm human macular area. Methods Twenty-four eyes with clinically significant macular edema (CSME) (12 eyes with and 12 eyes without central foveal involvement) underwent retinal thickness measurement (RT) and retinal sensitivity, performed by Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA, USA) and ...
Chorioretinal anastomosis and photodynamic therapy:a two-year follow-up study
Silva, Rufino; Cachulo, M.; Figueira, João; Abreu, José de; Cunha-Vaz, J.Abstract Background To evaluate the two-year efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomosis (CRA). Methods A non-randomized, institutional, prospective study, of 28 consecutive eyes of 23 patients, with CRA, treated with PDT. Masked best corrected visual acuity (VA) and angiographic features at baseline and duri...
Polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin
Silva, Rufino; Figueira, João; Cachulo, M.; Duarte, Liliane; Abreu, José Faria de; Cunha-Vaz, J.Abstract Background We evaluated, in a nonrandomised, institutional, prospective study, the efficacy of photodynamic therapy (PDT) with verteporfin in age-related macular degeneration (AMD) eyes with polypoidal choroidal vasculopathy (PCV) and subfoveal exudation. Methods A prospective clinical and angiographic study was done in 40 consecutive eyes with PCV treated with PDT using masked best-corrected visu...
Breakdown of the Inner and Outer Blood Retinal Barrier in Streptozotocin-Induce...
Carmo, Anália do; Ramos, Pedro; Reis, Aldina; Proença, Rui; Cunha-Vaz, J. G.Using vitreous fluorophotometry and quantitative fluorescence microscopy the authors studied the permeability of the blood-retinal barrier (BRB) to fluorescein in control and in 8 days streptozotocin-induced diabetic rats. ; http://www.sciencedirect.com/science/article/B6WFD-45JC7TK-T/1/ad834a7e41da87410003af7710548c3d
Microperfusion studies on the permeability of retinal vessels. A new model demo...
Murta, J. N.; Cunha-Vaz, J. G.; Sabo, C. A.; Jones, C. W.; Laski, M. E.We developed an experimental model to study the permeability of individual retinal vessels in vitro using microperfusion techniques adapted from kidney tubule studies. The retinal vessels were isolated by freehand dissection and mounted on a microperfusion apparatus. When inulin was perfused luminally, it was diluted to 80.2 +/- 2.3% of its initial concentration. However, no radioactive leak into the bath side ...
Future developments in ocular fluorophotometry instrumentation.
Leite, E B; Centro de Oftalmologia, Universidade de Coimbra, Hospitais da Universidade de Coimbra, Portugal.; Cunha-Vaz, J GThe scope of ocular fluorometry is to monitor exogenous and endogenous fluorophores in ocular tissues, in relation with ophthalmic and systemic diseases using the unique optical prospectives of the eye. The elderly population and the incidence of blindness are increasing rapidly due to more cases of diabetes, glaucoma, cataract and age-related macular degeneration. Monitoring changes in specific fluorophores in...
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