To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...
Validation of the Portuguese Version of the Pediatric Quality of Life InventoryTM (PedsQLTM) Cancer Module S. Santos1, C. Crespo1, M. C. Canavarro1, A. Fernandes2, L. Batalha2, & D. Campos2 1Faculty of Psychology and Educational Sciences and Institute of Cognitive, Developmental, Vocational and Social Psychology, University of Coimbra, Portugal 2Coimbra Nursing School, Portugal Introduction: The survival rate ...
Non-Hodgkin lymphoma (NHL) has been associated with immunological defects, chronic inflammatory and autoimmune conditions. Given the link between immune dysfunction and NHL, genetic variants in toll-like receptors (TLRs) have been regarded as potential predictive factors of susceptibility to NHL. Adequate anti-tumoral responses are known to depend on TLR9 function, such that the use of its synthetic ligand is b...
Non-Hodgkin lymphoma (NHL) has been associated with immunological defects, chronic inflammatory and autoimmune conditions. Given the link between immune dysfunction and NHL, genetic variants in toll-like receptors (TLRs) have been regarded as potential predictive factors of susceptibility to NHL. Adequate anti-tumoral responses are known to depend on TLR9 function, such that the use of its synthetic ligand is b...
Microdischarges at moderate to high pressure in argon were investigated. A hole opening diameter of 500 µm direct current (dc) microhollow cathode discharges (MHCD) were characterized by electrical measurements and optical emission spectroscopy (OES) for pressures ranging between 90 and 800 Torr and current from 5 to 20 mA. Current-voltage characteristic curves were obtained as a function of the pressure for th...
2010
Dilated fetal bowel is a sonographic fi nding that is associated to meconium ileus, a feature of cystic fi brosis (CF). Prenatal diagnosis of CF is possible through analysis of the cystic fi brosis transmembrane regulator gene mutations. A male infant is described, who was referred to our Prenatal Diagnosis Center a 17th week of gestation with a dilated bowel loop on a prenatal scan. Amniocentesis was performed...
There is a great concern in the literature for the development of neuroprotectant drugs to treat Parkinson's disease. Since anesthetic drugs have hyperpolarizing properties, they can possibly act as neuroprotectants. In the present study, we have investigated the neuroprotective effect of a mixture of ketamine (85 mg/kg) and xylazine (3 mg/kg) (K/X) on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or ...
The purpose of this study was to identify the kineanthropometrical parameters that best predict the maximal horizontal running force during d~ep-water tethered running.
A invasão de espécies arbóreas e arbustivas em áreas de campos limpos tem diminuído a capacidade produtiva das fazendas, prejudicando o setor pecuário da região.Estas variações podem ser causadas por distúrbios naturais (ciclos plurianuais de cheia e seca e de manejo (fogo, taxa de lotação animal, método de controle/limpeza). Visando auxiliar no entendimento do problema e na busca de soluções sustentáveis, o Ce...
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