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Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological act...
Coleta, Miguel; Campos, Maria Graça; Cotrim, Maria Dulce; Lima, Thereza Christina M. de; Cunha, António Proença daSince the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABAA receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Lute...
Neuropharmacological evaluation of the putative anxiolytic effects of Passiflor...
Coleta, Miguel; Batista, Maria Teresa; Campos, Maria Graça; Carvalho, Rui; Cotrim, Maria Dulce; Lima, Thereza Christina M. de; Cunha, António Proença daPassiflora edulis Sims together with several other plants of the genus Passiflora have been reported to possess anxiolytic properties. It has been suggested recently that flavonoids may be partly responsible for the neuropharmacological activity of these plants but there are still few data reporting the relation between the constituents of these plants and their activity. This work evaluated the anxiolytic/seda...
Quantification of tagitinin C in Tithonia diversifolia by reversed-phase high-p...
Goffin, Eric; Cunha, António Proença da; Ziemons, Eric; Tits, Monique; Angenot, Luc; Frederich, MichelA simple, rapid and reliable reversed-phase high-performance liquid chromatographic method for the determination of tagitinin C, an anti-plasmodial sesquiterpene lactone isolated from the aerial parts of Tithonia diversifolia, has been developed. The assay has been used to quantify tagitinin C in various extracts of the aerial parts of T. diversifolia. Copyright © 2003 John Wiley & Sons, Ltd. ; http://dx.doi...
Antimalarial activity of medicinal plants used in traditional medicine in S. To...
Madureira, Maria do Céu de; Martins, Ana Paula; Gomes, Milene; Paiva, Jorge; Cunha, António Proença da; Rosário, Virgílio doThe present study investigates the antimalarial activity of 13 medicinal plants used in traditional medicine in S. Tomé and Príncipe (STP) islands in the Gulf of Guinea, aiming at identifying the most effective plants for further research. Fieldwork was carried out with the collaboration of 37 traditional healers from both islands, during an ethnobotanical study, which was conducted from 1993 to 1999. Our resu...
Infraspecific chemical variability of the leaf essential oil of Juniperus phoen...
Cavaleiro, Carlos; Rezzi, Serge; Salgueiro, Ligia; Bighelli, Ange; Casanova, Joseph; Cunha, António Proença daThe essential oil composition of 68 individual plants of Juniperus phoenicea from Portugal was investigated by GC, GC-MS and 13C NMR. [alpha]-Pinene, [beta]-phellandrene, [alpha]-terpinyl acetate and myrcene were found to be the main constituents. Botanical and chemical data as well as phytogeographical distribution indicate J. phoenicea var. turbinata as the unique subspecies occurring in Portugal. Nevertheles...
Intraspecific chemical variability of the leaf essential oil of Juniperus phoen...
Rezzi, Serge; Cavaleiro, Carlos; Bighelli, Ange; Salgueiro, Ligia; Cunha, António Proença da; Casanova, JosephThe composition of 50 samples of essential oil of individual plants of Juniperus phoenicea subsp. turbinata from Corsica was investigated by GC, GC-MS and 13C NMR. [alpha]-Pinene, [beta]-phellandrene, [alpha]-terpinyl acetate, [Delta]-3-carene, myrcene and [alpha]-phellandrene were found to be the main constituents. The results were submitted to cluster analysis and discriminant analysis which allowed two group...
Essential oil composition and variability of Thymus lotocephalus and Thymus×mourae
Salgueiro, Lígia R.; Vila, Roser; Tomàs, Xavier; Cañigueral, Salvador; Paiva, Jorge; Cunha, António Proença da; Adzet, TomàsThe composition of the essential oils of four populations of Thymus lotocephalus G. López and R. Morales and one population of T.×mourae Paiva and Salgueiro, two endemic taxa from Portugal, was investigated mainly by GC and GC-MS. T×mourae is a natural hybrid between T. lotocephalus and T. mastichina (L.) L. subsp. donyanae R. Morales, which essential oil was analysed for the first time. In its oil, it was poss...
Chemotaxonomic study on Thymus villosus from Portugal
Salgueiro, Lígia R.; Vila, Roser; Tomàs, Xavier; Cañigueral, Salvador; Paiva, Jorge; Cunha, António Proença da; Adzet, TomàsThe composition of the essential oils of four populations of Thymus villosus subsp. lusitanicus (Boiss.) Coutinho from Portugal was investigated by GC and GC-MS. To study the chemical polymorphism the results obtained from GC analyses of the volatile oils from individual plants from four populations were submited to Principal Component and Cluster analyses. A comparision with the essential oil of T. villosus su...
Physicochemical attributes and pollen spectrum of Portuguese heather honeys
Andrade, Paula B.; Amaral, M. Teresa; Isabel, Paulo; Carvalho, João C. M. F.; Seabra, Rosa M.; Cunha, António Proença daThe qualities of selected honey samples of "Serra da Lousã" (Portugal) from three consecutive harvests (20 samples from each harvest) were evaluated by determing the pollen spectrum and physicochemical attributes. The following determinations were carried out: moisture, electrical conductivity, hydroxymethylfurfural, diastase activity, pH, acidity (free, lactone and total), formol number, reducing sugars, appar...
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