Encontrados 13 documentos, a visualizar página 1 de 2
Avaliação farmacológica e toxicológica do óleo essencial e extrato aquoso deLav...
Arantes, Silvia; Candeias, M. Fátima; Pereira, Marízia; Lopes, Orlando; Lima, Mónica; Cruz Morais, Júlio; Martins, M. RosárioAs plantas do género Lavandula L. pertencentes à família Labiatae, são plantas aromáticas de grande importância económica muito usadas na medicina tradicional. Neste estudo, foi selecionada uma espécie natural do Alentejo, Lavandula stoechas L. subsps. luisieri (Rozeira) Rozeira, vulgarmente conhecida por rosmaninho, recolhida de uma mancha da Herdade da Mitra (Évora) O objetivo deste estudo foi avaliar as ati...
Degradation of Metalaxyl and Folpet by Filamentous Fungi Isolated From Portugue...
Martins, M. Rosário; Pereira, Pablo; Lima, Nelson; Cruz-Morais, JúlioDegradation of xenobiotics by microbial populations is a potential method to enhance the effectiveness of ex situ or in situ bioremediation. The propose of this study was to evaluate the impact of repeated metalaxyl and folpet treatments on soil microbial communities and to select soil fungal strains able to degrade these fungicides. Results showed an enhanced degradation of metalaxyl and folpet in vineyards so...
Isoenzymatic expression of Na, K-ATPase in Langerhans islets of glucose intoler...
Costa, Ana R; Capela e Silva, Fernando; Antunes, Célia M; Cruz Morais, Júlio MNa,K-ATPase is ubiquitously expressed in all eukaryotic cells where it acts as a regulator of Na+ and K+ homeostasis. The Na,K-ATPase pump consists of (αβ)22. The α-subunit contains the catalytic and ligand binding sites. The β-subunit is a glycosylated protein, and its role in Na,K-ATPase enzyme function remains somewhat obscure. Four α- and three β-isoforms have been described in mammals. The isoenzymatic exp...
Chemical composition and pharmacological activities of essential oils of Lavand...
Martins, M. Rosário; Arantes, Silvia; Candeias, Fátima; Pereira, Marizia; Cruz-Morais, JúlioLavandula spp. belong to the family Lamiatae and some species are often used in popular medicine and have been used for centuries in a large number of medical applications and in aromatherapy. Although similar ethnobotanical properties of Lavandula spp., its essential oils, general chemical composition and therapeutic applications differ from different species. Lavandula stoechas L. subsps. luisieri (Rozeira) R...
Key role of AMPK in glucose-evoked Na,K-ATPase modulation
Rodrigues Costa, Ana; Capela e Silva, Fernando; Antunes, Célia; Cruz-Morais, JúlioBackground and aims: Na,K-ATPase is an integral membrane protein responsible for generating and maintaining transmembrane ionic gradients. It has been demonstrated that, in pancreatic β-cells, Na,K-ATPase is regulated by glucose and that this phenomenon is impaired in glucose intolerant subjects. However, the mechanism underlying glucose-induced modulation of Na,K-ATPase is still unclear. The AMP-activated prot...
CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF ESSENTIAL OILS OF LAVANDULA ...
Arante, Silvia; Martins, M. Rosário; Pereira, Marizia; Cruz-Morais, JúlioLavenders belong to the family Labiatae and represent some of the most popular medicinal plants of great economic importance. Their essential oils are important for the perfume, cosmetic, flavouring and pharmaceutical industries. However, despite its popularity, and the long tradition of use, biological properties of the various Lavandula species are not yet been well sustained by scientific or clinical studies...
Abnormal regulation of pancreatic beta cell Na,K-ATPase on glucose intolerant rats
Rodrigues Costa, Ana; Antunes, Celia M; Cruz-Morais, JúlioBackground and aims: Glucose (G) is the most important physiological insulin secretagogue. It is widely accepted that, in pancreatic -cell, G evoked early ionic events such as membrane depolarization and Ca2+ influx through voltage dependent Ca2+ channels triggers insulin exocytosis. However, the role of other electrogenic systems, namely ionic pumps, to these events remains essentially uninvestigated. It is k...
A new approach for determination of Na,K-ATPase activity: application to intact...
Costa, Ana R.; Real, Joana; Antunes, Célia M.; Cruz-Morais, JúlioIt has been postulated that a decrease in Na,KATPase-mediated ion gradients may be a contributing mechanism to insulin secretion. However, the precise role of the Na,K-ATPase in pancreatic β-cell membrane depolarization and insulin secretion signalling have been difficult to evaluate, mostly because data reporting changes in enzymatic activity have been obtained in cell homogenates or membrane preparations, lac...
Efeito Hipoglicemiante de um Extracto Aquoso de Cytisus multiflorus
Vieira, Ines P.; Costa, Ana Rodrigues; Teixeira, Dora M.; Antunes, Celia M.; Cruz-Morais, JulioEfeito Hipoglicemiante de um Extracto Aquoso de Cytisus multiflorus I. P. Vieira1, A. C. Costa1,2, D. M. Teixeira1,2,3, C. M. Antunes1,4 & J. Cruz-Morais1,2 1Departamento de Química; 2Instituto de Ciências Agrárias e Ambientais Mediterrânicas (ICAAM), 3Laboratório Hércules, Universidade de Évora, Largo dos Colegiais 2, 7000 Évora; 4Centro de Neurociências e Biologia Celular (CNC), Universidade de Coimbra, 30...
Alterações na modulação da Na,K-ATPase pela glicose em célula β-pancreática de ...
Costa, Ana Rodrigues; Antunes, Célia M.; Cruz-Morais, JulioAlterações na modulação da Na,K-ATPase pela glicose em célula β-pancreática de animais intolerantes à glicose AR Costa1,2, CM Antunes1,3, J Cruz-Morais1,2 1Departamento de Química, 2Instituto de Ciências Agrárias e Ambientais Mediterrânicas (ICAAM), Universidade de Évora, Largo dos Colegiais 2, 7000 Évora; 3Centro de Neurociências e Biologia Celular (CNC), Universidade de Coimbra, 3004-517 Coimbra;.acrc@uevora....
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