Encontrados 2 documentos, a visualizar página 1 de 1
Hydroxytamoxifen interaction with human erythrocyte membrane and induction of p...
Cruz Silva, M. M.; Madeira, V. M. C.; Almeida, L. M.; Custódio, J. B. A.4-Hydroxytamoxifen (OHTAM) is the most active metabolite of the widely prescribed anticancer drug tamoxifen (TAM) used in breast cancer therapy. This work describes the effects of OHTAM on isolated human erythrocytes, using standardized test conditions, to check for a putative contribution to the TAM-induced hemolysis and to study basic mechanisms involved in the interaction of OHTAM with cell membranes. Incuba...
Hemolysis of human erythrocytes induced by tamoxifen is related to disruption o...
Cruz Silva, M. M.; Madeira, Vítor M. C.; Almeida, Leonor M.; Custódio, José B. A.Tamoxifen (TAM), the antiestrogenic drug most widely prescribed in the chemotherapy of breast cancer, induces changes in normal discoid shape of erythrocytes and hemolytic anemia. This work evaluates the effects of TAM on isolated human erythrocytes, attempting to identify the underlying mechanisms on TAM-induced hemolytic anemia and the involvement of biomembranes in its cytostatic action mechanisms. TAM induc...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||