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Mycobacterium tuberculosis strains are differentially recognized by TLRs with a...

Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...

Mycobacterium ulcerans Triggers T-cell immunity followed by local and regional ...

Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-...

TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell ...

The authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry. ; CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-...

Competências na formação de Técnicos de Enfermagem para implementar a Sistemati...

Trata-se de pesquisa qualitativa, exploratória e descritiva, com o objetivo geral de conhecer, considerando a perspectiva do técnico de enfermagem que atua em hospital universitário, as competências desenvolvidas durante sua formação para implementar a Sistematização da Assistência de Enfermagem (SAE). A coleta e análise das informações ocorreram por meio de grupo focal, com técnicos de enfermagem e da análise ...

Opinião de visitantes sobre a sistemática de visitação a pacientes internados e...

O objetivo deste trabalho foi verificar se o atual sistema de visitação e informações satisfazem os visitantes dos pacientes internados em uma Unidade de Terapia Intensiva de um Hospital Universitário de grande porte. Para isto, foram distribuídos duzentos questionários aos visitantes, no período de um mês, destes retornaram cento e sessenta . A análise dos resultados evidencia que: 70% dos visitantes estão sat...

Práticas obstétricas e resultados maternos e neonatais: análise fatorial de cor...

OBJETIVO: Descrever as práticas obstétricas e os resultados maternos e neonatais de dois Centros de Parto Normal do Município de São Paulo, comparandose as unidades intra e extra-hospitalares. MÉTODOS: Estudo observacional, transversal e retrospectivo com dados secundários provenientes de 192 prontuários das instituições envolvidas. As variáveis de estudo foram as práticas selecionadas para o parto normal: a ut...

The selective COX-2 inhibitor etoricoxib reduces acute inflammatory markers in ...

The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. ; OBJECTIVE: A randomised experimental study was used to evaluate the therapeutic effect of a selective cyclooxygenase-2 (COX-2) inhibitor in neurogenic laryngitis. MATERIALS AND METHODS: Male Wistar Han rats were subjected to the nasogastric intubatio...

A new model of laryngitis : neuropeptide, cyclooxygenase, and cytokine profile

Cutting edge : IFN-γ regulates the induction and expansion of IL-17-producing C...

T cell responses are important to the control of infection but are deleterious if not regulated. IFN-γ-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN-γ-deficient mice have increased numbers of IL-17-...