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Nonsense-mediated decay resistance of AUG-proximal nonsense-mutated transcripts...

Apresentação oral por convite. ; Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing a premature termination codon (PTC). The unified model for NMD proposes that the decision of NMD triggering is the outcome of the competition between the cytoplasmatic poly(A)-binding protein 1 (PABPC1) and the NMD effector UPF1 for the termination complex. Consequ...

An upstream open reading frame regulates de translational efficiency of the hum...

Among the various cis-acting elements present in the 5’ leader sequence of mRNAs there are upstream open reading frames (uORFs). Although their function is still poorly understood, they are known to downregulate the main ORF expression of several human transcripts that code for key regulatory genes. The human erythropoietin (EPO) is a glycoprotein that was initially characterized has a hormone mainly synthesiz...

Translational control of the human hemojuvelin via upstream open reading frames

Iron is an essential element for many biological reactions carried out by living systems. A tight regulation of systemic iron homeostasis is crucial to avoid the pathological conditions of iron deficiency or overload. Juvenile hemochromatosis, is an early-onset inherited disorder associated to iron overload caused by mutations on the hepcidin gene or in the gene encoding hemojuvelin (HJV). HJV is a glycosylphos...

Alguns fatores determinantes dos resultados obtidos pelos alunos do 9º e 12º an...

A problemática deste estudo consiste em identificar alguns dos fatores que determinam os resultados escolares dos alunos (medidos através das classificações obtidas em exame nacional) e perceber se as escolas, enquanto organizações, também podem contribuir para o sucesso dos seus alunos. Assim, partindo do pressuposto de que há fatores extrínsecos e intrínsecos aos alunos e às escolas que podem “mascarar” (dimi...

Adhesive Joints for Vegetal Natural Fibres Reinforced Composites

Mechanical Characterisation of Sisal Fibres for Reinforcing of Composite Materi...

Single Filament Mechanical Characterisation of Hemp Fibres forReinforcing of Co...

Mechanical Characterisation of Natural Reinforced Plastics