Apresenta-se o caso clínico de uma adolescente de doze anos ade idade, que recorreu ao serviço de urgência por dor pré-cordial. Na auscultação cardíaca ouvia-se atrito pericárdico ao longo do bordo estemal esquerdo, sem outras alterações no exame objectivo. A teleradiografla do tórax em póstero-anterior revelou um espaço radiolucente à volta da sombra cardíaca limitado por uma fina membrana pericárdica bem defi...
Dissertação de Mestrado em Construção Sustentável apresentada à Escola Superior de Tecnologia do Instituto Politécnico de Castelo Branco. ; Desde a implementação do conceito do Novo Urbanismo, há mais de 50 anos até aos dias de hoje, arquitetos, projetistas e engenheiros têm vindo a adaptar a forma de pensar e projetar as construções futuras de modo a suprir as necessidades da presente geração sem comprometer ...
© Copyright – Escola Superior de Educação Paula Frassinetti; Universidade Católica Portuguesa - Porto
BACKGROUND/AIMS: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading to an intracellular accumulation of monocarboxylates such as lactate and pyruvate. These acids have an important role in cell metabolism and their rapid transport across the plasma membrane is crucial for the maintenance of intracellular pH homeostasis. This...
The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and oncostatin M (OSM). These cytokines share the membrane gp130 as a common signal transducer. Recently, it was demonstrated that IL-6 promotes, whereas LIF inhibits fetal lung branching...
O presente documento pretende descrever a experiência profissionalizante na vertente de farmácia comunitária e investigação e encontra-se dividido em dois capítulos. O capítulo 1 descreve as actividades realizadas ao longo do meu estágio curricular na Farmácia Comunitária Reis em Castelo Branco. Este capítulo consta de uma breve descrição desta farmácia bem como do funcionamento da mesma, das actividades desenv...
Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1)...
Conceived and designed the experiments: CN-S EC-D JC-P. Performed the experiments: CN-S PP EC-D FOP RSM. Analyzed the data: CN-S PP JC-P. Wrote the paper: CN-S PP RSM JC-P. ; Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are members of the family of the glycoprotein 130 (gp130)-type cytokines. These cytokines share gp130 as a common signal transducer, which explains why they show some functional re...
Uncorrected proof ; Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the ...
Tese de doutoramento em Medicina ; Pediatric and adult diseases characterized by lung hypoplasia or dysplasia are an epidemiological relevant issue, involving important morbidity and mortality rates. The understanding of the complex process of lung development, regulated by several genetic, chemical and physical determinants, has clinical relevance since it can open new perspectives in the treatment of these l...
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