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Diabetes changes the levels of ionotropic glutamate receptors in the rat retina
Santiago, Ana R.; Gaspar, Joana M.; Baptista, Filipa I.; Cristóvão, Armando J.; Santos, Paulo F.; Kamphuis, Willem; Ambrósio, António F.Purpose: Diabetic retinopathy (DR) is a leading cause of vision loss and blindness among adults between the age 20 to 74. Changes in ionotropic glutamate receptor subunit composition can affect retinal glutamatergic neurotransmission and, therefore, contribute to visual impairment. The purpose of this study was to investigate whether diabetes leads to changes in ionotropic glutamate receptor subunit expression ...
Development of chick retina cells in culture: cobalt entry through AMPA recepto...
Cristóvão, Armando J.; Carvalho, Caetana M.The functionality of [alpha]-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors in chick embryo retina cells during development in vitro was studied by using Co2+ uptake, and these data were correlated with the expression of the AMPA receptor subunit GluR4. We found that at 5 h in vitro only a small number of cells took up Co2+ upon stimulation with 100 [mu]M kainate or other AMPA receptor agonists...
Expression of AMPA/kainate receptors during development of chick embryo retina ...
Cristóvão, Armando J.; Oliveira, Catarina R.; Carvalho, Caetana M.The activity and the subunit expression of [alpha]-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate ionotropic glutamate receptors were studied in retina cells developing in chick embryos and in retina cells cultured as retinospheroids, at the same stages of development. In the retinospheroids, the activity of the AMPA/kainate receptors was monitored by following the changes in the intracellular fr...
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