Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, schis...
To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...
Background: Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and r...
Comunicação oral da qual só estão disponíveis o resumo e a apresentação. ; O presente ensaio foi elaborado segundo dois objetivos essenciais: explorar as ligações entre as pessoas e a desertificação dos territórios; levantar um conjunto de questões que consideramos serem relevantes na discussão e abordagem ao processo de planeamento no contexto do combate à desertificação. A lógica de abordagem utilizada centr...
O 1.º Seminário Raiano de Combate à Desertificação, realizado em Castelo Branco, em 20 e 21 de Janeiro de 2011, com o patrocínio dos Ministérios da Agricultura, do Desenvolvimento Rural e das Pescas de Portugal, do Ministério do Ambiente e do Meio Rural e Marinho de Espanha e do Conselheiro de Agricultura e Desenvolvimento Rural da Junta da Extremadura, focalizou-se nas problemáticas do Despovoamento e do Aband...
Com o apoio RAADRI. ; Abstract de apresentação de poster em conferência. ; Osteoporosis is a clinical condition characterized by an increased risk of bone fracture. Structural fragility seems to result from a reduction in bone mass due to a decreased mineral content and impaired/altered protein synthesis. Despite the established knowledge on osteoporosis, little is known on how these compositional changes may...
The main goal of this paper was to assess the greenhouse gas (GHG) intensity of olive oil production in Portugal. A life-cycle model and inventory were implemented for the entire production process, including a comprehensive analysis of olive cultivation, olive oil extraction, packaging, and distribution. Data originates from five differently-sized Portuguese olive growers and from a total of six olive oil mill...
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