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Clinical and genetic factors predicting response to therapy in patients with Cr...
Cravo, Marília; Ferreira, Paula; Sousa, Patrícia; Moura-Santos, Paula; Velho, Sónia; Tavares, Lurdes; Deus, João Ramos; Ministro, PaulaAim - To identify clinical and/or genetic predictors of response to several therapies in Crohn’s disease (CD) patients. Methods - We included 242 patients with CD (133 females) aged (mean ± standard deviation) 39 ± 12 years and a disease duration of 12 ± 8 years. The single-nucleotide polymorphisms (SNPs) studied were ABCB1 C3435T and G2677T/A, IL23R G1142A, C2370A, and G9T, CASP9 C93T, Fas G670A and LgC844T, a...
Risk factors for metabolic bone disease in Crohn's disease patients
Cravo, Marília; Guerreiro, Catarina Sousa; Santos, Paula Moura dos; Brito, Miguel; Ferreira, Paula; Fidalgo, Catarina; Tavares, LourdesBackground: The aim was to evaluate the presence of metabolic bone disease (MBD) in patients with Crohn’s disease (CD) and to identify potential etiologic factors. Methods: The case–control study included 99 patients with CD and 56 controls with a similar age and gender distribution. Both groups had dual-energy x-ray absorptionmetry and a nutritional evaluation. Single nucleotide polymorphisms at the IL1, TNF-a...
Fat intake interacts with polymorphisms of Caspase9, FasLigand and PPARgamma ap...
Ferreira, Paula; Cravo, Marília; Guerreiro, Catarina Sousa; Tavares, Lourdes; Santos, Paula Moura dos; Brito, MiguelBackground & aims: Crohn’s disease (CD) is a multifactorial disease where resistance to apoptosis is one major defect. Also, dietary fat intake has been shown to modulate disease activity. We aimed to explore the interaction between four single nucleotide polymorphisms (SNPs) in apoptotic genes and dietary fat intake in modulating disease activity in CD patients. Methods: Polymerase Chain Reaction (PCR) and Res...
Ecosapentanoic acid (EPA) does not affect cell kinetics in peripheral lymphocit...
Brito, Miguel; Ferreira, Paula; Guerreiro, Catarina Sousa; Malta-Vacas, Joana; Tavares, L.; Santos, P.; Pinto, A.; Cravo, MaríliaRationale: Omega 3 fatty acids have been shown to be of potential benefit in patients with CD. The aim of the present study was to evaluate whether EPA can modulate the inflammatory response according to different genotypes of IL6G174G/C polymorphism. Methods: Peripheral blood cells were collected from CD patients with different genotypes for IL6 174G/C (GG, n = 16, GC, n = 8, CC, n = 7), and lymphocytes were e...
Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methyl...
Guerreiro, Catarina Sousa; Carmona, Bruno; Gonçalves, Susana; Carolino, Elisabete; Fidalgo, Paulo; Brito, Miguel; Leitão, Carlos Nobre; Cravo, MaríliaBackground: Polymorphisms located in genes involved in the metabolism of folate and some methyl-related nutrients are implicated in colorectal cancer (CRC). Objective: We evaluated the association of 3 genetic polymorphisms [C677T MTHFR (methylene tetrahydrofolate reductase), A2756G MTR (methionine synthase), and C1420T SHMT (serine hydroxymethyltransferase)] with the intake of methyl-donor nutrients in CRC ris...
5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorecta...
Carmona, Bruno; Guerreiro, Catarina Sousa; Cravo, Marília; Leitão, Carlos Nobre; Brito, MiguelThymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' unstranslated region. Both of these may affect protein levels. The present case control study w...
The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in m...
Guerreiro, Catarina Sousa; Cravo, Marília; Brito, Miguel; Vidal, Pedro L.; Fidalgo, Paulo O.; Leitão, Carlos NobreBackground - Both genetic and environmental factors affect the risk of colorectal cancer (CRC). Objective - We aimed to examine the interaction between the D1822V polymorphism of the APC gene and dietary intake in persons with CRC. Design - Persons with CRC (n = 196) and 200 healthy volunteers, matched for age and sex in a case-control study, were evaluated with respect to nutritional status and lifestyle facto...
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