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Cryopreservation of cell laden natural origin hydrogels for cartilage regenerat...

The time span needed for obtaining a functional cartilage substitute using tissue engineering strategies, together with the need for specific patient oriented constructs has stimulated the growing interest for developing “off-the shelf” products. One way to deliver such products is based on long-term storage processes, such as cryopreservation, that will provide the clinical substitute available as needed and c...

Development of micro-patterned surfaces of poly(butylene succinate) by micromol...

Native tissues present complex architectures at the micro- and nanoscale that dictate their biological function. Several microfabrication techniques have been employed for engineering polymeric surfaces that could replicate in vitro these micro- and nanofeatures. In this study, biomimetic surfaces of poly(butylene succinate) (PBS) were engineered by a micromolding technique. After the optimization of the system...

Modulation of adipose tissue derived stem cells encapsulated in injectable mult...

Objective : The cellular microenvironment plays an important role in controlling the cellular behavior. Therefore, in Tissue Engineering strategies, systems have been designed so that by combining cells, signaling molecules and engineered substrates, one can mimic as closely as possible the native microenvironment of the extracellular matrix. In this context, injectable hydrogels have been developed that allow ...

Cryopreservation of cell laden natural origin hydrogels for cartilage regenerat...

Statement of Purpose: An increase of scientific published literature and clinical experience supports the requirement of providing products like cultured cells and tissues to the market. One of the main prospects of cartilage tissue engineering is the possibility of developing custom-made regenerative medicine solutions on an individual patient basis. The efficient preservation and storage procedure will provid...

Micro/nano-scale strategies for engineering in vitro the celular microenvironme...

Programa doutoral em Bioengenharia ; Biological tissues result of a specific spatial organization of cells, extracellular matrix (ECM) molecules, and soluble factors. These micro and nanoscaled biological entities organize into regional tissue architectures, creating highly complex and heterogeneous cellular microenvironments. To generate functional tissue equivalents in vitro, engineered biomaterials should m...

Natural-based photocrosslinkable polyelectrolyte complex hydrogel: development ...

Three-dimensional hydrogel mimics hierarchy and size of natural fiber bundles

Modified Gellan Gum hydrogels with tunable physical and mechanical properties

Gellan Gum (GG) has been recently proposed for tissue engineering applications. GG hydrogels are produced by physical crosslinking methods induced by temperature variation or by the presence of divalent cations. However, physical crosslinking methods may yield hydrogels that become weaker in physiological conditions due to the exchange of divalent cations by monovalent ones. Hence, this work presents a new clas...

The effect of chitosan on the in vitro biological performance of chitosan-poly(...

Chitosan blends with synthetic biodegradable polymers have been proposed for various biomedical applications due to their versatile mechanical properties and easier processing. However, details regarding the main surface characteristics that may benefit from the blending of these two types of materials are still missing. Hence, this work aims at investigating the surface properties of chitosan-based blends, ill...