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Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological act...
Coleta, Miguel; Campos, Maria Graça; Cotrim, Maria Dulce; Lima, Thereza Christina M. de; Cunha, António Proença daSince the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABAA receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin have been reported for their anxiolytic-like activity in different animal models of anxiety. Lute...
Neuropharmacological evaluation of the putative anxiolytic effects of Passiflor...
Coleta, Miguel; Batista, Maria Teresa; Campos, Maria Graça; Carvalho, Rui; Cotrim, Maria Dulce; Lima, Thereza Christina M. de; Cunha, António Proença daPassiflora edulis Sims together with several other plants of the genus Passiflora have been reported to possess anxiolytic properties. It has been suggested recently that flavonoids may be partly responsible for the neuropharmacological activity of these plants but there are still few data reporting the relation between the constituents of these plants and their activity. This work evaluated the anxiolytic/seda...
Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adr...
Cavadas, Cláudia; Grand, Daniela; Mosimann, François; Cotrim, Maria Dulce; Ribeiro, Carlos Alberto Fontes; Brunner, Hans R.; Grouzmann, EricThe aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. The NPY release is more sustained than that of catecholamines. We found that the recepto...
NPY regulates catecholamine secretion from human adrenal chromaffin cells
Cavadas, Cláudia; Silva, António P.; Mosimann, François; Cotrim, Maria Dulce; Ribeiro, Carlos Alberto Fontes; Brunner, Hans R.; Grouzmann, EricThe aim of the present work was to find out whether NPY synthesized in human adrenal chromaffin cells controls in an autocrine/paracrine fashion the release of catecholamines by these cells. Accordingly, the constitutive and regulated release of both NPY and catecholamines was measured simultaneously in cultured human chromaffin cells. In addition, by using both RT-PCR and a combination of specific agonists and...
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